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Infectious disease

HIV, drugs and the kidney

Authors: Nicola Wearne MBChB, FCP, MMed, Bianca Davidson MBChB, FCP, MMed, Marc Blockman MBChB, BPharm, PG Dip Int Res Ethics, MMed, Annoesjka Swart BScPharm, Erika SW Jones MBBCh, FCP, PhD

This review discusses antiretroviral therapy and its nephrotoxic effects, including drug–drug interactions. It aims to guide the clinician on dose adjustment in the setting of renal impairment and dialysis, for the commonly used drugs in patients with HIV.

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Pharmaceutical, clinical, and resistance information on doravirine, a novel non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infection

Authors: Hanh Thi Pham PhD, Meng A Xiao BSc, Miguel AV Principe BSc, Alexander Wong MD, Thibault Mesplède PhD

This review summarizes chemical, pharmacological, and clinical information about doravirine with an emphasis on drug resistance. The efficacy results from an early phase clinical trial evaluating doravirine in combination with islatravir are also provided.

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Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience

Authors: Felicia Pantò MD, Liboria Adamo BSc, Carla Giordano MD, Carmelo Licciardello MD

This is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). It focuses on the Zn(II)phthalocyanine derivative RLP608.

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Challenges and research priorities to progress the impact of antimicrobial stewardship

Authors: Matteo Bassetti MD, PhD, Daniele Roberto Giacobbe MD, Antonio Vena MD, PhD, Adrian Brink MMed

This review discusses and explains the most important challenges faced by antibiotic stewardship and antifungal stewardship programmes and suggests areas for further research.

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Oral oncolytic and antiretroviral therapy administration: dose adjustments, drug interactions, and other considerations for clinical use

Authors: Melissa E Badowski PharmD, MPH, Bradley Burton PharmD, Kristy M Shaeer PharmD, MPH, John Dicristofano BS, PharmD Candidate

This article evaluates existing literature through such means as drug databases and package inserts along with PubMed/Medline, Embase, and Google Scholar databases to develop a reference tool for providers to utilize when there is a decision to treat a patient with ART and oral oncolytic agents concurrently.

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