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Women’s health

Management of psoriasis in pregnancy – a review of the evidence to date

Authors: Clara Ferreira MD, Alexandra Azevedo MD, Miguel Nogueira MD, Tiago Torres MD, PhD

This article reviews the impact of psoriasis during pregnancy, how the disease can be managed pharmacologically during this period according to the available armamentarium, and the possible effects of the therapeutic options for the mother and the foetus.

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Hemorrhoid management in women: the role of tribenoside + lidocaine

Authors: Jan Kestřánek MD

This paper reviews various options in current therapy for hemorrhoids in women—namely, medical intervention (topical and systemic drug therapy)—and discusses the available clinical evidence for an appropriate use of over-the-counter topical formulations for the symptomatic treatment of hemorrhoids.

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Palbociclib in metastatic breast cancer: current evidence and real-life data

Authors: Francesco Serra MD, Pietro Lapidari MD, Erica Quaquarini MD, Barbara Tagliaferri MD, Federico Sottotetti MD, Raffaella Palumbo MD, PhD

This review summarizes the background and latest evidence for the use of palbociclib, an oral, first-in-class, highly selective cyclin-dependent kinase 4/6 inhibitor, in advanced breast cancer, with a focus on some of the unanswered questions about the performance of this agent in clinical practice.

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Menopause hormone therapy: latest developments and clinical practice

Authors: Tomas Fait MD, PhD

Menopause hormone therapy still remains a dominant
therapeutic modality in climacteric medicine. The core medical
skill is the ability to choose the optimal MHT preparation for
the given patient. Such choice is based on an understanding of
various clinical and metabolic effects of MHT depending on the
composition, dosage, and the method of application, this article discusses those choices.

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Anti-angiogenesis therapy, synthetic lethality, and checkpoint inhibition in ovarian cancer: state of the science and novel combinations

Authors: Marisa C Liu MD, MPH, Krishnansu S Tewari MD

This review summarizes studies related to anti-angiogenic treatment, synthetic lethality, and checkpoint inhibition of ovarian cancer and additionally novel combinations that offer a veritable therapeutic matrix for clinicians to choose from.

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