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Gastroenterology

Tofacitinib and newer JAK inhibitors in inflammatory bowel disease—where we are and where we are going

Authors: Eleanor Liu, Nasar Aslam, Gaurav Nigam, Jimmy K Limdi

This narrative review summarizes the current literature regarding the mechanism of action of tofacitinib, data from registrational trials, emerging real-world evidence, and an overview of the most recent safety evidence. The authors explore evolving treatment paradigms and also present a brief overview of the next generation of JAK inhibitors in the pipeline.

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Granulocyte and monocyte/macrophage apheresis in paediatric patients with ulcerative colitis: a case series in Spain

Authors: Javier Martin de Carpi

This case series shows the safety and efficacy of granulocyte monocyte/macrophage apheresis in paediatric ulcerative colitis, illustrating several granulocyte monocyte/macrophage apheresis uses.

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Impact of opioid-induced constipation on opioid substitution therapy management: the patient perspective

Authors: Fabio Lugoboni, Genevieve Hall, Vivek Banerji

This article explores the opinion of patients on the impact of constipation on the management of opioid substitution
treatment and quality of life.

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Paediatrics: how to manage functional constipation

Authors: Alexander KC Leung, Kam Lun Hon

This article provides a narrative updated review on the evaluation, diagnosis and management of childhood functional constipation.

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Paediatrics: how to manage viral gastroenteritis

Authors: Alexander KC Leung, Kam Lun Hon

This article aims to provide a narrative updated review on the evaluation and management of viral gastroenteritis in children.

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