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Gastroenterology

Second-line treatment options in hepatocellular carcinoma

Authors: Donatella Marino MD, Clizia Zichi MD, Marco Audisio MD, Elisa Sperti MD, Massimo Di Maio MD

This review discusses the evidence on second-line options for hepatocellular carcinoma, focusing on the latest results that are currently refining the treatment scenario.

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Regorafenib in hepatocellular carcinoma: latest evidence and clinical implications

Authors: Nicola Personeni MD, Tiziana Pressiani MD, Armando Santoro MD, Lorenza Rimassa MD

Over the past ten years, sorafenib has been the only systemic agent approved for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC) and in a second-line setting, most investigational drugs have failed to provide better survival outcomes than placebo. However, in 2016, data from the RESORCE trial, a phase 3 study evaluating regorafenib in HCC patients who experience disease progression after first-line treatment with sorafenib, have shown a 2.8-month median survival benefit over placebo (10.6 versus 7.8 months).

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Treatment of diverticular disease: an update on latest evidence and clinical implications

Authors: Marilia Carabotti MD, PhD, Bruno Annibale MD

This article summarizes the latest evidence and clinical implication in treatment of diverticular disease focusing either on the treatment of diverticulosis, symptomatic uncomplicated diverticular disease and acute diverticulitis together with the primary and secondary prevention of diverticulitis.

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Epidemiology and hospital resources use in the treatment of ulcerative colitis at gastroenterology units in Spain (EPICURE study)

Authors: Ignacio Marín-Jiménez MD, PhD, Cristina Saro MD, Verónica Díaz PhD, Manuel Barreiro-de Acosta MD, PhD, María Gómez-García MD, PhD, Ana Gutiérrez Casbas PhD, on behalf of the working group of EPICURE study

This article aims to assess the epidemiology of ulcerative colitis at hospital gastroenterology units and the use of hospital resources for the management of ulcerative colitis in Spain.

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Synchronous GISTs associated with multiple sporadic tumors: a case report

Authors: Danila Comandini, Azzurra Damiani, Alessandro Pastorino

The authors report a case of primary prostate and lung tumors associated with gastric and small bowel GISTs, unrelated to any known hereditary syndrome.

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