Nutritional support management in resectable gastric cancer

Francesco Serra, Paolo Pedrazzoli, Silvia Brugnatelli, Anna Pagani, Salvatore Corallo, Giovanni Rosti, Riccardo Caccialanza, Jacopo Viganò, Ornella Carminati

Article Type

Review

Published

This narrative review presents the most recent data on nutritional support in the resectable stages of gastric cancer, with a particular focus on perioperative strategies, and discusses malnutrition in gastric cancer, nutritional support before and after surgery, and the relationship between nutritional support and chemotherapy.

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Small bowel villous atrophy due to immune-checkpoint inhibitors: report of two cases and literature review

Annalisa Schiepatti, Andrea Premoli, Stiliano Maimaris, Mimma Rizzo, Maria Marples, Laura Villani, Nigel Scott, Federico Sottotetti, David S Sanders, Federico Biagi, Clare Donnellan

Article Type

Case Report

Published

This article describes two cases of enteropathy with villous atrophy due to immune-checkpoint inhibitors, which may broaden the differential diagnosis of non-coeliac enteropathies and may represent a pathogenetic model for the understanding of the molecular mechanisms involved in these enteropathies. A narrative review is also provided, summarizing the current evidence on the adverse events of immune-checkpoint inhibitors involving the small bowel.

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Tofacitinib and newer JAK inhibitors in inflammatory bowel disease – where we are and where we are going

Eleanor Liu, Nasar Aslam, Gaurav Nigam, Jimmy K Limdi

Article Type

Review

Published

This narrative review summarizes the current literature regarding the mechanism of action of tofacitinib, data from registrational trials, emerging real-world evidence, and an overview of the most recent safety evidence. The authors explore evolving treatment paradigms and also present a brief overview of the next generation of JAK inhibitors in the pipeline.

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