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Dermatology

Cutaneous side effects of molecularly targeted therapies for the treatment of solid tumors

Authors: Daniel I G Cubero MD, PhD, Beatrice Martinez Zugaib Abdalla MD, Jean Schoueri, Fabio Iazetti Lopes, Karine Corcione Turke, Jose Guzman MD, Auro Del Giglio MD, PhD, Carlos D’Apparecida Santos Machado Filho MD, PhD, Vanessa Salzano MD, Dolores Gonzalez Fabra MD

This article reviews the cutaneous side effects of main molecularly targeted cancer therapies for solid tumors.

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Emollient treatment of atopic dermatitis: latest evidence and clinical considerations

Authors: Kam Lun Hon MBBS, MD, FAAP, FCCM, Jeng Sum Charmaine Kung BSc, Wing Gi Gigi Ng BSc, Ting Fan Leung MBChB, MD, MRCP, FRCPCH

This article reviews current classes of emollients in the market, their clinical evidence in atopic dermatitis and considerations for choice of an emollient.

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Atopic dermatitis: a review of topical nonsteroid therapy

Authors: Ariana Papier BA, Lindsay C Strowd MD

This review focuses on the safety and efficacy of topical calcineurin and PDE4 inhibitors for the treatment of atopic dermatitis.

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Treatment with combined dabrafenib and trametinib in BRAFV600E-mutated metastatic malignant melanoma: a case of long-term complete response after treatment cessation

Authors: Sonia Brugnara, Mariacristina Sicher, Elena Maria Bonandini, Davide Donner, Franca Chierichetti, Mattia Barbareschi, Carlo Renè Girardelli, Orazio Caffo

The case report discusses a patient, diagnosed with BRAFV600E-mutated metastatic malignant melanoma M1a, who achieved a complete metabolic response after 7 months of treatment with the combination of dabrafenib and trametinib.

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Diagnosis and management of lentigo maligna: a review

Authors: Julia M Kasprzak, Yaohul G Xu

In lentigo maligna, the ill-defined nature and potentially large size of lesions can pose significant diagnostic and treatment challenges. The goal of therapy is to cure the lesions in order to prevent development of invasive disease. In this article the authors describe techniques for surgical excision, which is currently the treatment of choice to achieve clear histological margins, and review the evidence for nonsurgical treatment modalities.

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