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Cardiology and cardiovascular disease

Sacubitril/valsartan: evaluation of safety and efficacy as an antihypertensive treatment

Authors: Sarah L Anderson PharmD, Joel C Marrs PharmD

This review examines sacubitril/valsartan, which has demonstrated safety and efficacy when it comes to blood pressure lowering, making it a promising antihypertensive agent.

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Adding ezetimibe to statin therapy: latest evidence and clinical implications

Authors: Marija Vavlukis MD, PhD, FESC, Ana Vavlukis MSc

This review examines the therapeutic efficacy and safety of ezetimibe in combination therapy with statins and its potential side effects.

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Combination therapy in the treatment of hypertension

Authors: Carolina Guerrero-García MD, Alberto Francisco Rubio-Guerra PhD

This article reviews the latest information available regarding the treatment of hypertension with combination therapy.

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Cardiac myosin activators for heart failure therapy: focus on omecamtiv mecarbil

Authors: Edgardo Kaplinsky MD, Gordon Mallarkey PhD

This article examines omecamtiv mecarbil, which is a first-in-class cardiac myosin activator used in the treatment of heart failure.

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High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease

Authors: Constantine E Kosmas MD, PhD, Ian Martinez MD, Andreas Sourlas, Kyriaki V Bouza MD, Frederick N Campos MD, Verenisse Torres MD, Peter D Montan MD, Eliscer Guzman MD

This review aims to present and discuss the current clinical and scientific evidence pertaining to the significance of HDL functionality over the actual HDL-C concentration in mediating the favorable effects on the cardiovascular system.

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