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Cardiology and cardiovascular disease

DAPA-HF trial: dapagliflozin evolves from a glucose-lowering agent to a therapy for heart failure

Authors: Edgardo Kaplinsky MD

This review describes the results of the DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) trial and the recently published Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction (DEFINE-HF) trial. In addition, the thought-to-be mechanisms of action of SGLT2 inhibitors beyond their known glucose-lowering effects.

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Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues

Authors: Ashutosh M Shukla MD, Aparna Wagle Shukla MD

This article reviews the expanding clinical applicability of chloroquine and related drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections.

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Clinical profile and management of rivaroxaban in patients with atrial fibrillation in routine practice in Spain: data from six nationwide studies

Authors: Manuel Anguita MD, Mariano de la Figuera MD, Alejandro I Pérez Cabeza MD, Carmen Suarez Fernández MD

This work analyzed the clinical profile and management of patients with nonvalvular atrial fibrillation taking rivaroxaban in routine practice in Spain.

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Therapeutic management of hyperlipoproteinemia (a)

Authors: Constantine E Kosmas MD, PhD, Andreas Sourlas, Gordon Mallarkey PhD, Delia Silverio MD, Domingo Y Ynoa MD, Peter D Montan MD, Eliscer Guzman MD, Mario J Garcia MD

This review presents and discusses the current clinical and scientific data pertaining to the therapeutic options for the management of hyperlipoproteinemia (a).

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The benefits of antimicrobial photodynamic therapy with RLP068 in the management of diabetic foot ulcers

Authors: Nicolò Martinelli MD, Vincenzo Curci MD, Antonella Quarantiello MD, Gennaro Saldalamacchia MD

This article is the first part of a literature review concerning diabetic foot ulcers and the use of antimicrobial photodynamic therapy. The article reports previously published evidence and presents four, unpublished, clinical cases treated in the real-life setting.

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