Case Report
This article describes two cases of enteropathy with villous atrophy due to immune-checkpoint inhibitors, which may broaden the differential diagnosis of non-coeliac enteropathies and may represent a pathogenetic model for the understanding of the molecular mechanisms involved in these enteropathies. A narrative review is also provided, summarizing the current evidence on the adverse events of immune-checkpoint inhibitors involving the small bowel.
Review
This narrative review summarizes the current literature regarding the mechanism of action of tofacitinib, data from registrational trials, emerging real-world evidence, and an overview of the most recent safety evidence. The authors explore evolving treatment paradigms and also present a brief overview of the next generation of JAK inhibitors in the pipeline.
Case Series
This case series shows the safety and efficacy of granulocyte monocyte/macrophage apheresis in paediatric ulcerative colitis, illustrating several granulocyte monocyte/macrophage apheresis uses.
Original Research
This article explores the opinion of patients on the impact of constipation on the management of opioid substitution
treatment and quality of life.
Review
This article provides a narrative updated review on the evaluation, diagnosis and management of childhood functional constipation.