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Background of the study Breast cancer is increasingly diagnosed in older women (aged ≥70 years), a group of patients not often included in clinical trials. Treatment guidelines, based mainly on younger patients, do not fully account for the complex needs of older people, like the presence of multiple health conditions (comorbidities) and overall frailty. Hormone […]
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Background Children frequently experience allergic diseases, which may range from mild conditions to more severe diseases that may negatively affect their quality of life. In many paediatric allergic reactions, histamine causes allergyrelated symptoms, for example, itching, sneezing, hives and swelling. Antihistamine drugs are medications that relieve allergy symptoms by blocking the action of histamine, and […]
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Mild upper respiratory tract infections (MURTIs), sometimes incorrectly termed the ‘common cold’, are caused by viruses and affect the nose, sinuses, pharynx, and larynx. Symptoms often include sore throat, congestion, sneezing, headache, fatigue and cough, typically starting staggered but quickly progressing to a peak where multiple symptoms are present. Though generally self-limiting (resolving on their […]
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What is β-thalassaemia? β-Thalassaemia is a genetic blood disorder that can cause serious health problems, including an excess of iron in the body. This excess iron can lead to oxidative stress, which is like rust forming in your body and can damage important fats called LDL (low-density lipoprotein, or ‘bad cholesterol’). This damage can increase […]
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What is psoriasis? Psoriasis is a common, chronic skin disease that significantly affects the quality of life of those who have it due to red, scaly patches on the skin and associated health issues like psoriatic arthritis and heart disease. While the exact cause isn’t known, the IL-17–IL-23 axis – a pathway that drives chronic […]