Granulocyte and monocyte/macrophage apheresis in paediatric patients with ulcerative colitis: a case series in Spain

Article Page

Abstract

Paediatric ulcerative colitis (UC) can cause malnutrition and growth retardation but its treatment can be limited by the potential adverse events of corticosteroids and anti-TNF agents in children. However, adsorptive granulocyte monocyte/macrophage apheresis (GMA) using Adacolumn® reduces intestinal inflammation through multiple immunomodulatory effects. This case series shows the safety and efficacy of GMA in paediatric UC, illustrating several GMA uses: in chronically active UC, for corticosteroid reduction in steroid-dependent UC, in UC with secondary loss of response to anti-TNF therapy, as bridge therapy in UC with failure of anti-TNF therapy, and to substitute toxic drug treatments.

Keywords: adolescent, azathioprine, child, corticosteroids, granulocyte-monocyte apheresis, leukocytapheresis, paediatric ulcerative colitis, tumour necrosis factor inhibitors.

Citation: Martin de Carpi J. Granulocyte and monocyte/macrophage apheresis in paediatric patients with ulcerative colitis: a case series in Spain. Drugs Context. 2022;11:2021-10-6. https://doi.org/10.7573/dic.2021-10-6

Contributions: The named author meets the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, takes responsibility for the integrity of the work as a whole and has given their approval for this version to be published.

Disclosure and potential conflicts of interest: The author declares that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2022/02/dic.2021-10-6-COI.pdf

Acknowledgements: The author wishes to thank Content Ed Net (Madrid, Spain) and Carmen Acuña-Condal, MD, for their support in the preparation of this manuscript.

Funding declaration: Writing and editorial assistance was funded by Adacyte.

Copyright: Copyright © 2022 Martin de Carpi J. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2022 Martin de Carpi J. https://doi.org/10.7573/dic.2021-10-6. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/granulocyte-and-monocyte-macrophage-apheresis-in-paediatric-patients-with-ulcerative-colitis-a-case-series-in-spain

Correspondence: Javier Martin de Carpi, Unit for Integral Care of Paediatric Inflammatory Bowel Disease, Gastroenterology, Hepatology and Nutrition Department, Hospital Sant Joan de Déu, Barcelona, Spain. Email: javier.martinc@sjd.es

Provenance: Submitted; externally peer reviewed.

Submitted: 22 October 2021; Accepted: 27 January 2022; Publication date: 9 March 2022.

Drugs in Context is published by BioExcel Publishing Ltd. Registered office: Plaza Building, Lee High Road, London, England, SE13 5PT.

BioExcel Publishing Limited is registered in England Number 10038393. VAT GB 252 7720 07.

For all manuscript and submissions enquiries, contact the Editorial office editorial@drugsincontext.com

For all permissions, rights and reprints, contact David Hughes david.hughes@bioexcelpublishing.com

Download free full text PDF