Review and expert opinion on MAFLD, oxidative stress and multifunctional management

Francesco Angelico, Diana Alcantara-Payawal, Rafiz Abdul Rani, Norlaila Mustafa, Nuntakorn Thongtang, Roongruedee Chaiteerakij, Chalermrat Bunchorntavakul, Apichard Sukonthasarn

Article Type

Review

Published

This review summarizes the current knowledge about metabolic-associated fatty-liver disease (MAFLD) and reports the opinion of a group of experts on the increasing prevalence and burden of the disease in the southeast Asia region, the current journey of patients with MAFLD in developing countries, the role of oxidative stress and antioxidant treatment, and the importance of a multidisciplinary approach for early diagnosis and disease management.

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Diuretic resistance and the role of albumin in congestive heart failure

Carol Fernandez Hazim, Gustavo Duarte, Ana P Urena, Swati Jain, Rishabh Mishra, Timothy J Vittorio, Miguel Rodriguez-Guerra

Article Type

Review

Published

This review aims to expose the multiple approaches for treatment of patients with diuretic resistance and the importance of intravascular volume expansion in the response to therapy.

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Optimization of GDMT for patients with heart failure and reduced ejection fraction: can physiological and biological barriers explain the gaps in adherence to heart failure guidelines?

Marilyne Jarjour, Anique Ducharme

Article Type

Review

Published

The authors provide a comprehensive overview of clinicians’ adherence to heart failure guidelines in a specialized real-life setting, particularly regarding use and optimization of guideline-derived medical therapies, as well as the implementation of more recent agents. They seek potential explanations for suboptimal treatment and its impact on patient outcomes.

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Early experiences with edoxaban for stroke prevention in atrial fibrillation in the Southeast Asia region

Alejandro Bimbo Diaz, Jeremy Chow, Fan Kee Hoo, Kok Wei Koh, Gary Chin Keong Lee, Wee Siong Teo, Narayanaswamy Venketasubramanian, Chun-Chieh Wang, Radhika Mehta

Article Type

Case Series

Published

The authors share early clinical experiences with once-daily edoxaban and discuss its evidence-based use in patients with non-valvular atrial fibrillation in Southeast Asia through several cases of patients at high risk

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COVID-19 therapy and vaccination: a clinical narrative review

Siddharth Chinta, Miguel Rodriguez-Guerra, Mohammed Shaban, Neelanjana Pandey, Maria Jaquez-Duran, Timothy J Vittorio

Article Type

Review

Published

This review discusses how the SARS-CoV-2 pandemic has progressed and surged, and summarizes the safety and efficacy of the most used therapies and vaccines in the light of recent evidence.

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