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Cardiology and cardiovascular disease

Repurposing existing drugs for cardiovascular risk management: a focus on methotrexate

Authors: Arduino A Mangoni MD, PhD, FRCP, FRACP, Sara Tommasi PhD, Angelo Zinellu PhD, Salvatore Sotgia MSc, Ciriaco Carru PhD, Matteo Piga MD, Gian Luca Erre MD

This review discusses the current challenges in the management of cardiovascular disease; the available evidence on the effects of methotrexate on inflammation, blood pressure, and surrogate markers of arterial function; suggestions for future research directions; and practical considerations with the use of methotrexate in this context.

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Primary genetic disorders affecting high density lipoprotein (HDL)

Authors: Constantine E Kosmas MD, PhD, Delia Silverio MD, Andreas Sourlas, Frank Garcia MD, Peter D Montan MD, Eliscer Guzman MD

This review aims to describe certain genetic disorders associated with either low or high plasma HDL-C and discuss their clinical features, associated risk for cardiovascular events, and treatment options.

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Spectral Doppler and automated software-guided ultrasound assessment of bilateral common carotid intima-media thickness in spondyloarthritis: is there a correlation with clinical findings?

Authors: José Alexandre Mendonça PhD, Beatriz Bisetto de Andrade MD, José Luis Braga de Aquino PhD, Vania Aparecida Leandro-Merhi PhD, Guilherme B Damian MD

This study evaluates the correlation between articular and carotid ultrasound data and laboratory and clinical variables in patients with spondyloarthritis.

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Sacubitril/valsartan: evaluation of safety and efficacy as an antihypertensive treatment

Authors: Sarah L Anderson PharmD, Joel C Marrs PharmD

This review examines sacubitril/valsartan, which has demonstrated safety and efficacy when it comes to blood pressure lowering, making it a promising antihypertensive agent.

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Adding ezetimibe to statin therapy: latest evidence and clinical implications

Authors: Marija Vavlukis MD, PhD, FESC, Ana Vavlukis MSc

This review examines the therapeutic efficacy and safety of ezetimibe in combination therapy with statins and its potential side effects.

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