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Tag "Hypertension"

Sacubitril/valsartan: evaluation of safety and efficacy as an antihypertensive treatment

Authors: Sarah L Anderson PharmD, Joel C Marrs PharmD

This review examines sacubitril/valsartan, which has demonstrated safety and efficacy when it comes to blood pressure lowering, making it a promising antihypertensive agent.

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Combination therapy in the treatment of hypertension

Authors: Carolina Guerrero-García MD, Alberto Francisco Rubio-Guerra PhD

This article reviews the latest information available regarding the treatment of hypertension with combination therapy.

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Manidipine: an antihypertensive drug with positive effects on metabolic parameters and adrenergic tone in patients with diabetes

Authors: Margarita SaizSatjes, Francisco Javier Martinez-Martin

Examines combining a dihydropyridine calcium channel blocker with a renin-angiotensin-aldosterone system inhibitor for the treatment of diabetes

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Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes

Authors: Joshua J Neumiller

Type 2 diabetes is increasing in prevalence worldwide, and hyperglycemia is often poorly controlled despite a number of therapeutic options.

Unlike previously available agents, sodium-glucose co-transporter 2 inhibitors offer an insulin-independent mechanism for improving blood glucose levels, since they promote urinary glucose excretion by inhibiting glucose reabsorption in the kidney.

In this article, the author discusses empagliflozin and based on available data, it appears that this drug may be a useful option in a range of patients; however, clinical decisions will be better informed by the results of ongoing studies, in particular, a large cardiovascular outcome study (EMPA-REG OUTCOME™).

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