Manidipine: an antihypertensive drug with positive effects on metabolic parameters and adrenergic tone in patients with diabetes

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Antihypertensive treatment of patients with diabetes should include those drugs with a positive effect on metabolic parameters. Most patients with diabetes require at least two antihypertensive agents. Combining a dihydropyridine calcium channel blocker with a renin-angiotensin-aldosterone system inhibitor is a rational approach. However, not all dihydropyridines are equal with respect to their effects on metabolic parameters. Thus, manidipine exerts a positive effect on insulin resistance. However, this effect has not been observed with amlodipine. On the other hand, the excessive activation of sympathetic nervous system has been related with an increase of insulin resistance, pulse pressure, and ankle edema rates. Compared with amlodipine, manidipine activates sympathetic nervous system to a lesser extent. As a result, treatment with manidipine represents a good option in hypertensive patients with diabetes.

Keywords: amlodipine, antihypertensive drug, calcium channel blocker, diabetes, hypertension, insulin resistance, manidipine, sympathetic nervous system.

Citation: SaizSatjes M, Martinez-Martin FJ. Manidipine: an antihypertensive drug with positive effects on metabolic parameters and adrenergic tone in patients with diabetes. Drugs in Context 2018; 7: 212509. DOI: 10.7573/dic.212509

Disclosure and potential conflicts of interest: The authors have no conflicts of interest to declare. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at:

Acknowledgments: Editorial assistance was provided by Content Ed Net, Madrid, Spain.

Funding declaration: The preparation of this manuscript was funded by Chiesi.

Copyright: Copyright © 2018 SaizSatjes M, Martinez-Martin FJ. Distributed under the terms of the Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2018 SaizSatjes M, Martinez-Martin FJ. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

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Correspondence: Margarita Saiz Satjes, Hospital Universitario Mutua Terrassa, Plaça del Doctor Robert, 5, 08221 Terrassa, Barcelona, Spain.

Provenance: submitted; externally peer reviewed.

Submitted: 10 October 2017; Peer review comments to author: 22 November 2017; Revised manuscript received: 4 December 2017; Accepted: 4 December 2017; Publication date: 3 January 2018.

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