Articles

A paradigm shift for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer: a review of CDK inhibitors

Mariane Teodoro Fernandes MD, Jacob J Adashek BA, Carmelia Maria Noia Barreto MD, Ana Cláudia Barbin Spinosa MD, Barbara de Souza Gutierres MSc, Gilberto Lopes MD, MBA, FAMS, Auro del Giglio MD, PhD, Pedro Nazareth Aguiar Jr MD, MSc

Article Type

Review

Published

A novel class of targeted therapy has been approved for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. There are currently three approved agents, which are oral cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. In this review, all available data is summarized, unanswered questions are highlighted, and pharmacological differences between each CDK4/6 inhibitor are discussed.

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Eosinophilic fasciitis: a case series with an emphasis on therapy and induction of remission

Rechelle Tull MD, William D Hoover III MD, Jacqueline F De Luca MD, William W Huang MD, MPH, Joseph L Jorizzo MD

Article Type

Original Research

Published

Eosinophilic fasciitis is an uncommon connective tissue disorder. Systemic corticosteroids can induce remission of disease; however, there is no universally accepted treatment ladder for eosinophilic fasciitis. This case series evaluates treatment efficacy in patients with eosinophilic fasciitis.

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The biosimilars journey: current status and ongoing challenges

Igor Age Kos MD, Valderílio Feijó Azevedo MD, PhD, Daniel Egg Neto, Sérgio Cândido Kowalski MD, PhD

Article Type

Review

Published

Biosimilar products are already approved and marketed in several countries. This review focuses on remaining challenges regarding biosimilars, such as the lack of regulatory harmony, especially concerning naming, the marketed intended copies, the interchangeability, and the biosimilars in orphan diseases.

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Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA

Louise Destrée BPsych (Hons), Danielle Amiet BPsych (Hons), Adrian Carter PhD, Rico Lee PhD, Valentina Lorenzetti PhD, Rebecca Segrave PhD, George Youssef PhD, Nadia Solowij PhD, Murat Yücel PhD

Article Type

Original Research

Published

This study investigated whether the legal status of cannabis in the USA is associated with problematic cannabis use and impulsivity in frequent cannabis users.

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