Plain Language Summary: Effectiveness of the antihistamine and anti-PAF effects of rupatadine in allergic diseases: off-label use in a case series study

Rita Aguiar, Rocío Concepción Albores-Arguijo, Ewa Cichocka-Jarosz, Joanna Jerzynska, Douglas P Mack

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Background Children frequently experience allergic diseases, which may range from mild conditions to more severe diseases that may negatively affect their quality of life. In many paediatric allergic reactions, histamine causes allergyrelated symptoms, for example, itching, sneezing, hives and swelling. Antihistamine drugs are medications that relieve allergy symptoms by blocking the action of histamine, and […]

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Plain Language Summary: Holistic care in mild upper respiratory tract infections (MURTIs): an approach to individualized care management

Andrew Smith, Guillermo Estrada Riolobos, Marco Biagi, Andreas Michalsen, Laura Sadofsky, Ann Herzeel, Patrick Poucheret

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Mild upper respiratory tract infections (MURTIs), sometimes incorrectly termed the ‘common cold’, are caused by viruses and affect the nose, sinuses, pharynx, and larynx. Symptoms often include sore throat, congestion, sneezing, headache, fatigue and cough, typically starting staggered but quickly progressing to a peak where multiple symptoms are present. Though generally self-limiting (resolving on their […]

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Plain Language Summary: Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE

Ngan Thi Tran, Pakawit Lerksaipheng, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Ken-ichi Yamada, Noppawan Phumala Morales, Rataya Luechapudiporn

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What is β-thalassaemia? β-Thalassaemia is a genetic blood disorder that can cause serious health problems, including an excess of iron in the body. This excess iron can lead to oxidative stress, which is like rust forming in your body and can damage important fats called LDL (low-density lipoprotein, or ‘bad cholesterol’). This damage can increase […]

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Plain Language Summary: Biologics and small molecules for psoriasis: current and future progress

Luca Potestio, Nello Tommasino, Michela D’Agostino, Valeria Esposito, Giuseppe Lauletta, Antonio Portarapillo, Matteo Megna

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What is psoriasis? Psoriasis is a common, chronic skin disease that significantly affects the quality of life of those who have it due to red, scaly patches on the skin and associated health issues like psoriatic arthritis and heart disease. While the exact cause isn’t known, the IL-17–IL-23 axis – a pathway that drives chronic […]

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Plain Language Summary: N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care

Francesca Benedetti, Pierachille Santus

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What is N-acetylcysteine? N-acetylcysteine (NAC) is a medication often used to help people with lung conditions that involve thick mucus such as bronchitis, pneumonia and cystic fibrosis. It works by thinning mucus, making it easier to clear from the lungs. It also has other helpful effects, for example, it can reduce inflammation, protect lung tissue […]

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