Plain Language Summary: The convergent pathway of obstructive lung disease: the disease-modifying potential of dipeptidyl peptidase 1 inhibition in COPD, asthma and bronchiectasis overlap

Francesco Menzella, Marcello Cottini, Carlo Lombardi, Rory Chan

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The challenge: overlapping lung diseases and uncontrolled inflammation For many years, clinicians treated chronic lung diseases like asthma and chronic obstructive pulmonary disease (COPD) as separate problems. However, we now know that these conditions often overlap, especially with bronchiectasis — a condition where the airways are permanently damaged and widened. This overlap creates severe syndromes […]

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Plain Language Summary: Optimizing care and quality indicators in the management of patients with acute ischaemic heart disease and atherothrombotic stroke: measuring to improve

José R González-Juanatey, Rafael Vázquez-García, Raquel Campuzano, José Luis Zamorano, María Isabel Egocheaga, Vicente Pascual Fuster, Ana Martín Sanz, Angels Pedragosa Vall, Jaime Masjuan

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What was this study about? Acute ischemic heart disease (AIHD) and atherothrombotic stroke (AS) are serious cardiovascular conditions and major causes of death and long-term disability worldwide. These disorders share similar biological mechanisms, mainly driven by a process called atherothrombosis. Patient outcomes depend greatly on fast, high-quality emergency treatment and consistent long-term followup. However, the […]

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Plain Language Summary: Role of a topical hydrogel (Dermatix® wound care gel) in acute and chronic wound management: a case series of real-world experiences and expert opinion from Asia

Chin Yen Lee, Elizabeth Wei Hsi Chang, Khong Yik Chew, Vilvkumaran Karupayah, Wildan Latief, Vi Anh Le, Dohar Tobing, Thi Phuong Thao Vu, Kean Chew Wong

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Role of a topical hydrogel (Dermatix® wound care gel) in acute and chronic wound management: a case series of real-world experiences and expert opinion from Asia This article presents real-world experience and expert opinions from Asian clinicians regarding the use of Dermatix® Wound Care (DWC) gel, an acidified hydrogel, in managing diverse acute and chronic […]

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Plain Language Summary: Apremilast in osteoarthritis: exploring its therapeutic mechanisms

Farzad Rafiei, Saina Sadeghipour, Seyed Mohammad Hosseini Marvast, Ali Mandegary, Hamidreza Soltani

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Apremilast: mechanisms of its therapeutic effect in osteoarthritis Osteoarthritis (OA) is often mistakenly viewed as simple ‘wear-and-tear’ disease. However, it is now recognized as a complex, chronic disease involving low-grade inflammation, oxidative stress, and damage to cartilage and the underlying bone. This destructive cycle is driven by pro-inflammatory signals, primarily proteins called cytokines (like IL-17 […]

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Plain Language Summary: Sphingosine-1-phosphate receptor modulators in ulcerative colitis – a narrative review of current evidence and practical considerations

Anish J Kuriakose Kuzhiyanjal, Karishma Sethi-Arora, Gaurav B Nigam, Jimmy K Limdi

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Published

What is ulcerative colitis and how is it treated? Ulcerative colitis is a chronic, relapsing and remitting condition that predominantly affects the large bowel. Some people with moderate or severely active ulcerative colitis require advanced therapy in the form of biological or small-molecule drugs (called advanced therapies) to maintain control of their symptoms. What advanced […]

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