Plain Language Summary: Biologics and small molecules for psoriasis: current and future progress

Luca Potestio, Nello Tommasino, Michela D’Agostino, Valeria Esposito, Giuseppe Lauletta, Antonio Portarapillo, Matteo Megna

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Plain Language Summary

Published

What is psoriasis? Psoriasis is a common, chronic skin disease that significantly affects the quality of life of those who have it due to red, scaly patches on the skin and associated health issues like psoriatic arthritis and heart disease. While the exact cause isn’t known, the IL-17–IL-23 axis – a pathway that drives chronic […]

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Plain Language Summary: N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care

Francesca Benedetti, Pierachille Santus

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Plain Language Summary

Published

What is N-acetylcysteine? N-acetylcysteine (NAC) is a medication often used to help people with lung conditions that involve thick mucus such as bronchitis, pneumonia and cystic fibrosis. It works by thinning mucus, making it easier to clear from the lungs. It also has other helpful effects, for example, it can reduce inflammation, protect lung tissue […]

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Plain Language Summary: Place in therapy of key treatments for platinum-sensitive, relapsed, extensive-stage small cell lung cancer with a focus on lurbinectedin: a narrative review with case studies

Leonid Shunyakov, Firas B Badin, Judith Hafer, David König, Patrizia Froesch, Laurent Greillier

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Plain Language Summary

Published

Background About 2 out of 3 individuals who present to a doctor with symptoms of small cell lung cancer (SCLC) will be diagnosed with advanced disease. Standard treatment with platinum-etoposide plus atezolizumab or durvalumab is highly effective; however, virtually all patients who respond to this primary (first-line) treatment will become resistant to platinum and relapse. […]

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Plain Language Summary: JAK inhibitors for the treatment of palmoplantar pustulosis: a narrative review

Beatriz Henriques dos Santos, João Domingues, Marco Sousa, Tiago Torres

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Plain Language Summary

Published

Palmoplantar pustulosis (PPP) is a chronic, inflammatory skin disease characterized by sterile pustules on the palms and/or soles. These lesions often fissure, causing significant pain, functional impairment and reduced quality of life. The disease predominantly affects women in middle age and is strongly associated with smoking. PPP is challenging to treat as it often responds […]

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Plain Language Summary: Management of refractory generalized myasthenia gravis with eculizumab during pregnancy and puerperium: a case report

Bedriye Karaman, Rasim Tunçel, Özgül Ekmekci, Nurten Uzun Adatepe, Nur Yüceyar

Article Type

Plain Language Summary

Published

This article presents a case study about a young woman with a severe form of myasthenia gravis (MG), a disease that causes muscle weakness. Her condition was so severe that it was considered ‘refractory’, meaning that it didn’t respond well to standard treatments. The patient had tried several medications, but her symptoms, including difficulty walking […]

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