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Tag "myofibroblast"

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Authors: Allan R Brasier MD, Istvan Boldogh DM&B, PhD

This article reviews recent systems-level studies that provide fundamental new insights into how repetitive activation of innate signaling pathways produce epigenetic ‘training’ to induce adaptive epithelial responses and presents studies demonstrating efficacy of these in reducing airway inflammation in preclinical models