Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents

Gabriela Antelo MD, Cinta Hierro MD, MSc, Juan Pablo Fernández MD, Eduardo Baena MD, Cristina Bugés MD, Laura Layos MD, José Luis Manzano MD, Mónica Caro MD, Ricard Mesia MD, PhD

Article Type

Review

Published

This article discusses the current management of this rare entity and provide an overview of the most relevant molecular findings, whilst illustrating the potential value that prescreening panels can offer, searching for actionable targets (MSI/dMMR, PD-L1, BRAFv600E) to guide therapy with promising agents that could fill a void in this disease.

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Second-line treatment options in hepatocellular carcinoma

Donatella Marino MD, Clizia Zichi MD, Marco Audisio MD, Elisa Sperti MD, Massimo Di Maio MD

Article Type

Review

Published

This review discusses the evidence on second-line options for hepatocellular carcinoma, focusing on the latest results that are currently refining the treatment scenario.

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