Primary therapy for chronic obstructive pulmonary disease (COPD) is the removal of the toxic agent (in most cases, tobacco smoke). Additional therapy includes bronchodilators. Inhaled corticosteroids and long-acting bronchodilators can be used to prevent and reduce the risk of exacerbations. COPD is a systemic disease and often requires therapy of its protean-associated morbidities from depression to osteoporosis and muscle wasting. Despite pessimism from some, COPD is treatable.