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Tag "effectiveness"

Tofacitinib and newer JAK inhibitors in inflammatory bowel disease—where we are and where we are going

Authors: Eleanor Liu, Nasar Aslam, Gaurav Nigam, Jimmy K Limdi

This narrative review summarizes the current literature regarding the mechanism of action of tofacitinib, data from registrational trials, emerging real-world evidence, and an overview of the most recent safety evidence. The authors explore evolving treatment paradigms and also present a brief overview of the next generation of JAK inhibitors in the pipeline.


Antidepressant efficacy and side-effect burden: a quick guide for clinicians

Authors: Daniel Santarsieri, Thomas L Schwartz

Prescribing of antidepressant treatment (ADT) for major depressive disorder (MDD) has increased substantially over the last two decades. In this paper, the authors discuss the evidence that supports the use of ADT based on FDA approvals, data from randomized controlled trials or meta-analyses and where these are not available, the authors discuss and apply theoretical pharmacodynamic principles to help guide treatment choice in MDD.