The convergent pathway of obstructive lung disease: the disease-modifying potential of dipeptidyl peptidase 1 inhibition in COPD, asthma and bronchiectasis overlap

Francesco Menzella, Marcello Cottini, Carlo Lombardi, Rory Chan

Article Type

Review

Published

This review synthesizes the pathophysiology and key aspects of bronchiectasis–COPD overlap syndrome and analyses the clinical evidence for brensocatib as the first potential disease-modifying therapy for this neutrophilic endotype designed to break the cycle.

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Oscillococcinum® for upper respiratory tract infections and exacerbations in COPD: an observational, prospective study (OXITUNIS)

Hichem Aouina, Anis Bamri, Aurélien Vesin, Karine Danno, Eléonore Aubry, Cécile Faure, Naoual Boujedaini

Article Type

Original Research

Published

This article discussese the effectiveness of Oscillococcinum® in the protection from upper respiratory tract infections in patients with chronic obstructive pulmonary disease who had been vaccinated against influenza infection over the 2018–2019 winter season.

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Clinical factors, including All Patient Refined Diagnosis Related Group severity, as predictors of early rehospitalization after COPD exacerbation

Melissa H Roberts, Douglas W Mapel, Ann Von Worley, Janice Beene

Article Type

Original Research

Published

Patients hospitalized for chronic obstructive pulmonary disease (COPD) exacerbations carry a high risk for early rehospitalization. This study demonstrates that hospitals can use commonly collected clinical information to help identify COPD patients at a high risk of failure after discharge.

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One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA

Susan T Arthur, Joshua M Noone, Bryce A Van Doren, Debosoree Roy, Christopher M Blanchette

Article Type

Original Research

Published

Cachexia is a condition characterized as a loss in body mass or metabolic dysfunction and it is associated with several prevalent chronic health conditions including many cancers, COPD, HIV, and kidney disease. Currently there is little research into cachexia and the objective of this article is to characterize cachexia patients, their healthcare utilisation, and associated hospitalization costs.

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