Anticoagulation for the prevention of stroke in non-valvular AF in general practice: room for improvement

Adam Ioannou, Sofia Metaxa, George Kassianos, Constantinos G Missouris

Article Type

Original Research

Published

The aim of this study was to assess whether the recommendations and guidelines for thromboprophylaxis in patients with atrial fibrillation (AF) have been adopted in general practice (GP) in the UK. The authors concluded that one in four patients with non-valvular AF, at risk of a stroke, is not being adequately treated with an oral anticoagulant in primary care and suggest that a review of GP practice databases should be considered to identify patients with non-valvular AF, at risk of a disabling or fatal event, and measures taken to initiate anticoagulant therapy.

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Hemodynamic effect of avanafil and glyceryl trinitrate coadministration

Dennis Swearingen, Ajay Nehra, Susie Morelos and Craig A Peterson

Article Type

Original Research

Published

In this study, investigators examined the magnitude and duration of the interactions (when coadministered with glyceryl trinitrate) of the latest phosphodiesterase type-5 inhibitor avanafil on systolic blood pressure and heart rate compared with sildenafil and placebo.

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