Breast cancer, one of the most common malignancies worldwide, is an example of complex disease. Clinical complexity is an increasingly recognized feature of internal medicine and oncology patients, who are often characterized by multifaceted needs determined by both biological (i.e. intrinsic to patient or disease biology) and non-biological (i.e. socioeconomic, cultural, environmental and behavioural) factors. In this series, we try to provide a comprehensive view of breast cancer complexity from a clinical and molecular perspective, with the aim of improving our understanding of the disease and patient care.

Tackling the clinical complexity of breast cancer

Marco Vincenzo Lenti, Federico Sottotetti, Gino Roberto Corazza

Article Type

Commentary

Published

The authors provide their view about the possible factors triggering clinical complexity, the key issues of clinical complexity and the related unmet needs in breast cancer.

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The prognostic role of variations in tumour markers (CEA, CA15.3) in patients with metastatic breast cancer treated with CDK4/6 inhibitors

Federico Sottotetti, Elisa Ferraris, Barbara Tagliaferri, Raffaella Palumbo, Erica Quaquarini, Cristina Teragni, Emanuela Balletti, Claudia Leli, Andrea Premoli, Ludovica Mollica, Silvia Puglisi, Silvia Sardi, Alberto Malovini, Paolo Pedrazzoli, Antonio Bernardo

Article Type

Original Research

Published

In this real-life study, the authors aim to evaluate the prognostic role of variations in cancer antigen 15.3 (CA15.3) and carcinoembryonic antigen (CEA) levels in patients with HR+/HER2− breast cancer treated with CDK4/6 inhibitors. The goal of this investigation is to consider whether it would be possible to use these markers as a monitoring tool to diagnose earlier, faster and in a more practical way.

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