Articles - Page 93 of 96 - Drugs in Context

Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes

Joshua J Neumiller

Article Type

Review

Published

11 Jun 2014

Type 2 diabetes is increasing in prevalence worldwide, and hyperglycemia is often poorly controlled despite a number of therapeutic options.

Unlike previously available agents, sodium-glucose co-transporter 2 inhibitors offer an insulin-independent mechanism for improving blood glucose levels, since they promote urinary glucose excretion by inhibiting glucose reabsorption in the kidney.

In this article, the author discusses empagliflozin and based on available data, it appears that this drug may be a useful option in a range of patients; however, clinical decisions will be better informed by the results of ongoing studies, in particular, a large cardiovascular outcome study (EMPA-REG OUTCOME™).

Study protocol for a randomized, controlled trial comparing the efficacy of two educational interventions to improve inhalation techniques in patients with chronic obstructive pulmonary disease (COPD): TIEPOC Study.

José Leiva-Fernández, Francisca Leiva-Fernández, Rubén L Vázquez-Alarcón, Antonio García-Ruiz, Daniel Prados-Torres, Pilar Barnestein-Fonseca

Article Type

Case Report

Published

24 Apr 2014

Up to 75% of patients with COPD do not use a correct inhaler technique. In this article, the authors provide details of a study protocol for a randomized controlled trial to test the efficacy of two educational interventions aimed at improving inhalation techniques in a cohort of patients in southern Spain.

Tardive dyskinesia in patients treated with atypical antipsychotics: case series and brief review of etiologic and treatment considerations

Jungjin Kim, Eric MacMaster, Thomas L Schwartz

Article Type

Case Report

Published

09 Apr 2014

Tardive dyskinesia (TD) can be a disfiguring side-effect of antipsychotic medications. In this article the authors review the risk of TD, the potential etiologic mechanisms and present some interesting cases of patients taking atypical antipsychotics who developed TD.

The non-anticoagulation costs of atrial fibrillation management: findings from an observational study in NHS Primary Care

George Kassianos, Chris Arden, Simon Hogan, Laura Baldock, Ahmet Fuat

Article Type

Original Research

Published

09 Apr 2014

Atrial fibrillation (AF) management represents a significant burden on the UK NHS. In this article the authors review data from 825 patients in routine UK clinical practice and describe the non-anticoagulation costs associated with AF management. Understanding these costs better may help inform future health care planning and policy development.

Probabilistic data linkage: a case study of comparative effectiveness in COPD

Christopher M Blanchette, Mitch DeKoven, Ajita P De, Melissa Roberts

Article Type

Original Research

Published

31 Oct 2013

In this era of comparative effectiveness research, new, advanced techniques are being investigated by the research community to overcome the limitations of existing data sources. In this article Dr Christopher Blanchette and his co-authors describe the approach of probabilistic data linkage as a means to address this critical issue.