Plain Language Summary: Place in therapy of key treatments for platinum-sensitive, relapsed, extensive-stage small cell lung cancer with a focus on lurbinectedin: a narrative review with case studies

Leonid Shunyakov, Firas B Badin, Judith Hafer, David König, Patrizia Froesch, Laurent Greillier

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Plain Language Summary

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Background About 2 out of 3 individuals who present to a doctor with symptoms of small cell lung cancer (SCLC) will be diagnosed with advanced disease. Standard treatment with platinum-etoposide plus atezolizumab or durvalumab is highly effective; however, virtually all patients who respond to this primary (first-line) treatment will become resistant to platinum and relapse. […]

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Plain Language Summary: JAK inhibitors for the treatment of palmoplantar pustulosis: a narrative review

Beatriz Henriques dos Santos, João Domingues, Marco Sousa, Tiago Torres

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Plain Language Summary

Published

Palmoplantar pustulosis (PPP) is a chronic, inflammatory skin disease characterized by sterile pustules on the palms and/or soles. These lesions often fissure, causing significant pain, functional impairment and reduced quality of life. The disease predominantly affects women in middle age and is strongly associated with smoking. PPP is challenging to treat as it often responds […]

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Plain Language Summary: Management of refractory generalized myasthenia gravis with eculizumab during pregnancy and puerperium: a case report

Bedriye Karaman, Rasim Tunçel, Özgül Ekmekci, Nurten Uzun Adatepe, Nur Yüceyar

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Plain Language Summary

Published

This article presents a case study about a young woman with a severe form of myasthenia gravis (MG), a disease that causes muscle weakness. Her condition was so severe that it was considered ‘refractory’, meaning that it didn’t respond well to standard treatments. The patient had tried several medications, but her symptoms, including difficulty walking […]

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Plain Language Summary: Tezepelumab for early-onset severe allergic asthma with persistent airflow limitation and small airway dysfunction: a treatable traits approach

Francesco Menzella, Claudio Sorino, Carlo Lombardi, Annamaria Bosi, Silvia Tonin, Lorenzo Corsi, Andrea Ballarin, Marcello Cottini

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Plain Language Summary

Published

Case summary: tezepelumab for allergic asthma This case report details the successful treatment of a young woman with severe allergic asthma using a new medication called tezepelumab. Patient’s condition and treatment challenge The patient was an 18-year-old woman with a long history of severe asthma that was not well-controlled, even with advanced inhaler therapy. A […]

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