Plain Language Summary
What is β-thalassaemia? β-Thalassaemia is a genetic blood disorder that can cause serious health problems, including an excess of iron in the body. This excess iron can lead to oxidative stress, which is like rust forming in your body and can damage important fats called LDL (low-density lipoprotein, or ‘bad cholesterol’). This damage can increase […]
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What is psoriasis? Psoriasis is a common, chronic skin disease that significantly affects the quality of life of those who have it due to red, scaly patches on the skin and associated health issues like psoriatic arthritis and heart disease. While the exact cause isn’t known, the IL-17–IL-23 axis – a pathway that drives chronic […]
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What is N-acetylcysteine? N-acetylcysteine (NAC) is a medication often used to help people with lung conditions that involve thick mucus such as bronchitis, pneumonia and cystic fibrosis. It works by thinning mucus, making it easier to clear from the lungs. It also has other helpful effects, for example, it can reduce inflammation, protect lung tissue […]
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Background About 2 out of 3 individuals who present to a doctor with symptoms of small cell lung cancer (SCLC) will be diagnosed with advanced disease. Standard treatment with platinum-etoposide plus atezolizumab or durvalumab is highly effective; however, virtually all patients who respond to this primary (first-line) treatment will become resistant to platinum and relapse. […]
Plain Language Summary
Palmoplantar pustulosis (PPP) is a chronic, inflammatory skin disease characterized by sterile pustules on the palms and/or soles. These lesions often fissure, causing significant pain, functional impairment and reduced quality of life. The disease predominantly affects women in middle age and is strongly associated with smoking. PPP is challenging to treat as it often responds […]