The convergent pathway of obstructive lung disease: the disease-modifying potential of dipeptidyl peptidase 1 inhibition in COPD, asthma and bronchiectasis overlap

Francesco Menzella, Marcello Cottini, Carlo Lombardi, Rory Chan

Article Type

Review

Published

This review synthesizes the pathophysiology and key aspects of bronchiectasis–COPD overlap syndrome and analyses the clinical evidence for brensocatib as the first potential disease-modifying therapy for this neutrophilic endotype designed to break the cycle.

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Holistic care in mild upper respiratory tract infections (MURTIs): an approach to individualized care management

Andrew Smith, Guillermo Estrada Riolobos, Marco Biagi, Andreas Michalsen, Laura Sadofsky, Ann Herzeel, Patrick Poucheret

Article Type

Review

Published

This article presents a patient-centred classification system for mild upper respiratory tract infections and proposes a 360° holistic care model that tailors effective, safe and suitable treatment to each individual’s symptoms and circumstances.

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N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care

Francesca Benedetti, Pierachille Santus

Article Type

Review

Published

This narrative review evaluates the efficacy and safety of N-acetylcysteine in paediatric acute and chronic respiratory diseases, synthesizing data from clinical trials, observational studies and real-world evidence, with a particular focus on optimizing dosing based on patient-specific characteristics.

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Tezepelumab for early-onset severe allergic asthma with persistent airflow limitation and small airway dysfunction: a treatable traits approach

Francesco Menzella, Claudio Sorino, Carlo Lombardi, Annamaria Bosi, Silvia Tonin, Lorenzo Corsi, Andrea Ballarin, Marcello Cottini

Article Type

Case Report & Review

Published

This article describes the clinical and functional evolution of a young patient with severe early-onset allergic asthma with impaired respiratory function treated with the anti-thymic stromal lymphopoietin biologic agent tezepelumab.

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Dupilumab reduces patient-reported cough and improves quality of life in patients with severe eosinophilic asthma with or without chronic rhinosinusitis with nasal polyps: a real-life prospective study

Carlo Lombardi, Alvise Berti, Francesco Menzella, Marcello Cottini

Article Type

Original Research

Published

The objective of this study was to assess the impact of dupilumab on chronic cough in patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps.

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