10 years of real-world data: long-term efficacy and safety of HyalOne® for hip osteoarthritis

Alberto Migliore, Nazzareno Iannarelli, Luca Saccone, Francesca Giovannangeli, Umberto Massafra, Orazio de Lucia, Annamaria Paglionico, Sergio Crimaldi, Eugenio Cunego, Raffaele Saporito, Gabriele al Khayyat Suhel, Giovanni Boni

Article Type

Original Research

Published

This study provides the first real-world evidence of the sustained efficacy and safety of a 10-year ultrasound-guided HyalOne® injection regimen in managing hip osteoarthritis, highlighting significant improvements in pain, function and non-steroidal anti-inflammatory
drug reduction across diverse patient populations.

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Three once-weekly intra-articular injections of Hylan G-F 20 significantly improve pain relief compared with placebo in patients with chronic idiopathic knee osteoarthritis: a single-centre, evaluator-blinded and patient-blinded, randomized controlled trial

Michael Langworthy, Peter Lascarides, Wilson Ngai, Kevin Steele, Yili Huang

Article Type

Original Research

Published

This study was conducted to determine the efficacy and safety of three once-weekly injections of intra-articular Hylan G-F 20 in patients with chronic knee osteoarthritis over 26 weeks. It was hypothesized that Hylan G-F 20 would provide significant pain relief with no increased safety risk compared with IA saline (placebo).

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