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Haematology and Oncology

Temozolomide and oral etoposide in children with recurrent malignant brain tumors

Authors: Antonio Ruggiero MD, Anna Ariano MD, Silvia Triarico MD, Michele Antonio Capozza MD, Alberto Romano MD, Palma Maurizi MD, Stefano Mastrangelo MD, Giorgio Attinà MD

The article reviews the results
derived from the combination use of TMZ and oral VP-16 to treat malignant brain tumors

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Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents

Authors: Gabriela Antelo MD, Cinta Hierro MD, MSc, Juan Pablo Fernández MD, Eduardo Baena MD, Cristina Bugés MD, Laura Layos MD, José Luis Manzano MD, Mónica Caro MD, Ricard Mesia MD, PhD

This article discusses the current management of this rare entity and provide an overview of the most relevant molecular findings, whilst illustrating the potential value that prescreening panels can offer, searching for actionable targets (MSI/dMMR, PD-L1, BRAFv600E) to guide therapy with promising agents that could fill a void in this disease.

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Facing the COVID-19 outbreak in children with cancer

Authors: Antonio Ruggiero MD, Alberto Romano MD, Giorgio Attinà MD

This editorial discusses the current COVID-19 outbreak and underlines that hygienic educational programs are fundamental and must be continued and implemented especially for immunosuppressed children.

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Use of anti-CD20 therapy in follicular and marginal zone lymphoma: a review of the literature

Authors: Luis Miguel Juárez-Salcedo MD, Diego Conde-Royo MD, Keina Quiroz-Cervantes MD, Samir Dalia MD

This article discusses the role of mAbs in follicular lymphoma and marginal zone lymphoma along with reviewing the current data about the use of biosimilar mAbs in these diseases.

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Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management

Authors: Antonio Ruggiero MD, Palma Maurizi MD, Silvia Triarico MD, Michele Antonio Capozza MD, Stefano Mastrangelo MD, Giorgio Attinà MD

This paper describes two case studies of infants with multifocal infantile haemangiomatosis and hepatic involvement. A review of current therapeutic approaches is also presented.

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