Haematology and Oncology Archives

Adjuvant abemaciclib in early-stage breast cancer: hypothesis-generating safety observations from a real-world cohort study

Federico Sottotetti, Simone Figini, Giulia Gambini, Gianpiero Rizzo, Giulia Chessa, Erica Quaquarini, Raffaella Palumbo, Lorenzo Perrone, Barbara Tagliaferri, Alessandra Ferrari, Catherine Klersy, Paolo Pedrazzoli, Laura Deborah Locati, Angioletta Lasagna

Article Type

Original Research

Published

11 Dec 2025

This study aims to enhance comprehension of the clinical efficacy and safety of adjuvant abemaciclib in older women in a real-world setting compared with younger women.

Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE

Ngan Thi Tran, Pakawit Lerksaipheng, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Ken-ichi Yamada, Noppawan Phumala Morales, Rataya Luechapudiporn

Article Type

Original Research

Published

02 Dec 2025

This study assesses the protective effect of deferiprone on the oxidative status of low-density lipoproteins in patients with β-thalassaemia/haemoglobin E.

Multimodal treatment of pineal metastasis from oesophageal adenocarcinoma

Francesca Rifaldi, Domiziana Alaimo, Anna Tortorella, Ilaria Imarisio, Anna Pagani, Salvatore Corallo, Paolo Pedrazzoli, Daniela Cicognini, Viola Custodi, Francesco Guerrini, Giannantonio Spena, Elisabetta Bonzano, Sara Colombo, Jacopo Viganò, Luca Ansaloni, Anna Gallotti, Alessandra Viglio, Francesco Serra

Article Type

Case Report

Published

31 Oct 2025

The authors present a case of pineal metastasis from oesophageal adenocarcinoma managed by multimodal treatment and compare their observations with the available literature on this disease entity.

Place in therapy of key treatments for platinum-sensitive, relapsed, extensive-stage small cell lung cancer with a focus on lurbinectedin: a narrative review with case studies

Leonid Shunyakov, Firas B Badin, Judith Hafer, David König, Patrizia Froesch, Laurent Greillier

Article Type

Review

Published

29 Oct 2025

This article reviews key second-line regimens recommended in major guidelines for treatment of patients with extensive-stage small cell lung cancer with platinum-sensitive relapse (chemotherapy-free interval ≥90 days), focusing on recent prospective clinical trials and post hoc analyses.

Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases

Vanda Salutari

Article Type

Editorial

Published

24 Jun 2025

This editorial introduces the special series in Drugs in Context that explores treatment advancements for endometrial cancer through clinical case studies.