Spectral Doppler and automated software-guided ultrasound assessment of bilateral common carotid intima-media thickness in spondyloarthritis: is there a correlation with clinical findings?

Article Details

Authors
José Alexandre Mendonça PhD, Beatriz Bisetto de Andrade MD, José Luis Braga de Aquino PhD, Vania Aparecida Leandro-Merhi PhD, Guilherme B Damian MD

Article Type
Original Research

DOI
10.7573/dic.212538

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Abstract

Background and aim: Limited information is currently available about whether carotid intima-media thickness (IMT) correlates with the degree of disease activity in spondyloarthritis. The objective of this study was to evaluate the correlation between articular and carotid ultrasound data and laboratory and clinical variables in patients with spondyloarthritis.

Methods: Twenty-two patients with spondyloarthritis, recruited consecutively via the spondyloarthritis service of the Universidade Pontifícia Católica de Campinas, São Paulo, Brazil, were assessed using carotid artery ultrasound (radiofrequency quality intima-media thickness, RF-QIMT), joint ultrasound, clinical evaluation, and laboratory tests.

Results: Mean (standard deviation, SD) carotid RF-QIMT was 0.643 (0.16) mm. Mean (SD) resistive index (RI) values for the right and left carotid arteries were 0.67 (0.12) and 0.82 (0.38), respectively. Mean (SD) RI values for the right and left sacroiliac joints were 1.10 (0.97) and 0.94 (0.13), respectively. Several significant correlations were detected between ultrasound, clinical, and laboratory variables. Notably, there were correlations between sacroiliac RI and erythrocyte sedimentation rate (p=0.027) and RF-QIMT (p=0.037); between RF-QIMT and Framingham score (p=0.012) and metabolic parameters, including abdominal waist measurement, body mass index (BMI) (p=0.032 to p=0.044).

Conclusions: In patients with spondyloarthritis, RF-QIMT detected atherosclerotic changes in the carotid artery wall, and spectral Doppler detected inflammatory activity in sacroiliac joints. Positive correlations were observed between these ultrasound findings and parameters reflecting patients’ metabolic profile and alterations in inflammatory markers.

Keywords: atherosclerosis, carotid artery, inflammation, sacroiliac joint, spectral Doppler, spondyloarthritis, ultrasonography.

Citation: Mendonça JA, Bisetto de Andrade B, Braga de Aquino JL, Leandro-Merhi VA, Damian GB. Spectral Doppler and automated software-guided ultrasound assessment of bilateral common carotid intima-media thickness in spondyloarthritis: is there a correlation with clinical findings? Drugs in Context 2018; 7: 212538. DOI: 10.7573/dic.212538

Contributions: All the medical team of the Pontifical Catholic University of Campinas contributed with the methodological and clinical aspects. Guilherme B Damian was accountable for medical writing and is a full-time employee of UCB, Sao Paulo, Brazil.

Disclosure and potential conflicts of interest: The authors declare no conflict of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at https://www.drugsincontext.com/wp-content/uploads/2018/08/dic.212538-COI.pdf

Acknowledgments: Editorial assistance was provided by Content Ed Net (Brazil) with funding from UCB Biopharma S/A, São Paulo, Brazil.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2018 Mendonça JA, Bisetto de Andrade B, Braga de Aquino JL, Leandro-Merhi VA, Damian GB. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2018 Mendonça JA, Bisetto de Andrade B, Braga de Aquino JL, Leandro-Merhi VA, Damian GB. https://doi.org/10.7573/dic.212538. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/spectral-doppler-and-automated-software-guided-ultrasound-assessment-of-bilateral-common-carotid-intima-media-thickness-in-spondyloarthritis-is-there-a-correlation-with-clinical-findings

Correspondence: José Alexandre Mendonça, Sumaré, São Paulo, CEP 13175-665, Brazil. mendoncaja.us@gmail.com

Provenance: submitted; externally peer reviewed.

Submitted: 21 May 2018; Peer review comments to author: 25 June 2018; Revised manuscript received: 6 August 2018; Accepted: 7 August 2018; Publication date: 3 September 2018.

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