Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management

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Abstract

Infantile haemangiomas (IHs) are the most common benign tumours of childhood; despite the benign histology, prognosis depends on severity of visceral involvement, with a mortality rate ranging from 50 to 90%. In this paper, we describe two infants with multifocal infantile haemangiomatosis and hepatic involvement. This condition should receive appropriate management as it can be potentially lethal due to the high risk of systemic complications such as cardiac or fulminant hepatic failure and abdominal compartment syndrome. Both cases presented with liver involvement, but only the infant who had an excellent response to propranolol is still alive. A review of current therapeutic approaches is also presented even though there are, at present, no uniform guidelines for treatment, despite the relative frequency of infantile haemangiomatosis and the potential severe complications.

Keywords: hepatic haemangioma, infant, medical treatment, multifocal infantile haemangiomatosis.

Citation: Ruggiero A, Maurizi P, Triarico S, Capozza MA, Mastrangelo S, Attinà G. Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management. Drugs in Context 2020; 9: 2019-11-5. DOI: 10.7573/dic.2019-11-5

Contributions: All authors contributed equally to the preparation of this review. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2020/02/dic.2019-11-5-COI.pdf

Acknowledgements: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2020 Ruggiero A, Maurizi P, Triarico S, Capozza MA, Mastrangelo S, Attinà G. https://doi.org/10.7573/dic.2019-11-5. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2020 https://doi.org/10.7573/dic.2019-11-5. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/multifocal-infantile-haemangiomatosis-with-hepatic-involvement:-two-cases-and-treatment-management/

Correspondence: Antonio Ruggiero, MD, Paediatric Oncology Unit, A. Gemelli Hospital, Catholic University of Rome, Largo A. Gemelli 8, 00168 Rome, Italy. antonio.ruggiero@unicatt.it

Provenance: submitted; externally peer reviewed.

Submitted: 23 November 2019; Peer review comments to author: 30 December 2019; Revised manuscript received: 19 February 2020; Accepted: 19 February 2020; Publication date: 26 March 2020.

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