A non-pharmacological approach to the treatment of urinary tract infections: case reports with Utipro® Plus

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Abstract

Recurrent urinary tract infections (UTIs) can profoundly impair patients’ quality of life and carry a substantial health resource burden. Although antibiotics are the mainstay of treatment, interest is growing in identifying antibiotic-sparing alternatives. Utipro® Plus is a medical device that acts as a mechanical barrier to protect the intestinal lumen against the adherence and invasion of uropathogenic strains of Escherichia coli. It is intended for the control and prevention of UTIs caused by E. coli and other Gram-negative uropathogens. Using illustrative case reports, this review documents outcomes in three women with recurrent UTIs who were treated with Utipro® Plus in clinical practice.

Keywords: antimicrobial resistance, antimicrobial stewardship, quality of life, recurrent urinary tract infections, Utipro® Plus.

Citation: Cai T, Konstantinidis C, Ward S. A non-pharmacological approach to the treatment of urinary tract infections: case reports with Utipro® Plus. Drugs in Context 2021; 10: 2021-2-2. DOI: 10.7573/dic.2021-2-2

Contributions: The authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: TC has received travelling and speaking grants from Noventure. CKG has served as a freelance medical advisor for pharmaceutical and biotech companies including Devicare, Ferrer and Noventure. SW has served as a consultant for Goodlife (propiverine) and Merck (Cran Fyt Plus). The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2021/05/dic.2021-2-2-COI.pdf

Acknowledgements: Medical writing assistance was provided by Kerry Dechant of behalf of Content Ed Net (Madrid, Spain), with funding by Noventure SL, Barcelona, Spain. This manuscript is a review article and does not involve a research protocol requiring approval by a relevant institutional review board or ethics committee.

Funding declaration: Writing assistance was funded by Noventure SL, Barcelona, Spain.

Copyright: Copyright © 2021 Cai T, Konstantinidis C, Ward S. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2021 Cai T, Konstantinidis C, Ward S. https://doi.org/10.7573/dic.2021-2-2. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/a-non-pharmacological-approach-to-the-treatment-of-urinary-tract-infections:-case-reports-with-utipro-plus

Correspondence: Tommaso Cai, Department of Urology, Santa Chiara Regional Hospital, Largo Medaglie d’Oro, 9, Trento, Italy. Email: ktommy@libero.it

Provenance: Submitted; externally peer reviewed.

Submitted: 16 February 2021; Accepted: 13 April 2021; Publication date: 24 May 2021.

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