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Tag "antimicrobial resistance"

Infectious disease: how to manage Gram-positive and Gram-negative pathogen conundrums with dual beta-lactam therapy

Authors: Alireza FakhriRavari, Brenda Simiyu, Taylor Morrisette, Yewande Dayo, Jacinda C Abdul-Mutakabbir

This article reviews the mechanisms of beta-lactam resistance in Gram-positive and Gram-negative bacteria, discusses the rationale for dual beta-lactam use against multidrug-resistant infections (and other scenarios in which this strategy may be most utilized in clinical practice), explores the available in vitro, in vivo and clinical data, and provides considerations for the use of dual beta-lactam therapy against Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii pathogens.


A non-pharmacological approach to the treatment of urinary tract infections: case reports with Utipro® Plus

Authors: Tommaso Cai, Cristian Konstantinidis, Sam Ward

Using illustrative case reports, this review documents outcomes in three women with recurrent urinary tract infections who were treated with Utipro® Plus in clinical practice.


Drugs in Context Editorial: Review of 2020 and what lies ahead in therapeutic interventions

Authors: Sarah L Anderson, Matteo Bassetti, Arduino A Mangoni

The Senior Editors of Drugs in Context provide us with their expert opinion on the events of 2020 and what lies ahead in 2021.


Challenges and research priorities to progress the impact of antimicrobial stewardship

Authors: Matteo Bassetti MD, PhD, Daniele Roberto Giacobbe MD, Antonio Vena MD, PhD, Adrian Brink MMed

This review discusses and explains the most important challenges faced by antibiotic stewardship and antifungal stewardship programmes and suggests areas for further research.