Transdermal buprenorphine for pain management in children

Article Details

Authors
Giorgio Attinà, Alberto Romano, Silvia Triarico, Stefano Mastrangelo, Palma Maurizi, Antonio Ruggiero

Article Type
Review

DOI
10.7573/dic.2021-6-1

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Abstract

Pain is one of the main symptoms reported by sick children, particularly by those suffering from cancer. Opioids are very useful in controlling this symptom but they are burdened with significant side effects that limit their use in children. Buprenorphine is a strong opioid that, due to its particular pharmacological characteristics, ensures excellent pain relief with fewer side effects than other opioids. The transdermal formulation allows for good pain control associated with optimal compliance by patients and few limitations on daily life. Unfortunately, transdermal buprenorphine use remains off-label for the control of chronic pain in children; therefore, it is desirable that new studies can validate its use in the paediatric population. This review aims to analyse the clinical advantages of transdermal buprenorphine in the paediatric population and the possible side effects registered in daily clinical practice.

Keywords: buprenorphine, children, opioids, pain, transdermal.

Citation: Attinà G, Romano A, Triarico S, Mastrangelo S, Maurizi P, Ruggiero A. Transdermal buprenorphine for pain management in children. Drugs Context. 2021;10:2021-6-1. https://doi.org/10.7573/dic.2021-6-1

Contributions: Conceptualization, GA and AR; methodology, GA and PM; validation, AR and SM; data curation, ST; writing – original draft preparation, GA, AR; writing, review and editing, AR; visualization, SM; supervision, AR. All authors have read and agreed to the published version of the manuscript. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2021/08/dic.2021-6-1-COI.pdf

Acknowledgements: The authors thank the ‘Carriero Family’ for their support to the paediatric research in remembrance of Carriero Lino.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2021 Attinà G, Romano A, Triarico S, Mastrangelo S, Maurizi P, Ruggiero A. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2021 Attinà G, Romano A, Triarico S, Mastrangelo S, Maurizi P, Ruggiero A. https://doi.org/10.7573/dic.2021-6-1. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/transdermal-buprenorphine-for-pain-management-in-children

Correspondence: Antonio Ruggiero, Paediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy. Email: antonio.ruggiero@unicatt.it

Provenance: Invited; externally peer reviewed.

Submitted: 1 June 2021; Accepted: 6 August 2021; Publication date: 14 September 2021.

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