Topical treatment of radiation-induced dermatitis: current issues and potential solutions

Article Details

Authors
Nicola Alessandro Iacovelli MD, Yvan Torrente MD, PhD, Adriana Ciuffreda MD, Vittorio A Guardamagna MD, PhD, Marta Gentili MS, Luca Giacomelli PhD, Paola Sacerdote PhD

Article Type
Review

DOI
10.7573/dic.2020-4-7

Related Articles

Article Page

Abstract

Approximately 95% of patients receiving radiotherapy (RT) will ultimately develop radiation-induced dermatitis (RID) during or after the course of treatment, with major consequences on quality of life and treatment outcomes. This paper reviews the pathophysiology of RID and currently used topical products for the prevention and treatment of RID. Although there is no consensus on the appropriate management, recent evidence suggests that the use of topical products supports to protect and promote tissue repair in patients with RID. Basic recommendations include advice to wear loose clothing, using electric razors if necessary, and avoiding cosmetic products, sun exposure or extreme temperatures. Based on mechanisms involved and on the clinical characteristics of oncological patients, the profile of the ideal topical product for addressing RID can be designed; it should have limited risk of adverse events, systemic adsorption and drug–drug interactions, should be characterized by multiple clinical activities, with a special focus on localized pain, and should have a careful formulation as some vehicles can block the RT beam.

Keywords: pain, quality of life, radiation-induced dermatitis, radiotherapy, skin toxicity, topical treatment.

Citation: Iacovelli NA, Torrente Y, Ciuffreda A, Guardamagna AV, Gentili M, Giacomelli L, Sacerdote P. Topical treatment of radiationinduced dermatitis: current issues and potential solutions. Drugs in Context 2020; 9: 2020-4-7. DOI: 10.7573/dic.2020-4-7

Contributions: All authors contributed equally to the preparation of this review. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: LG is the owner of Polistudium, the consultancy agency involved in the editorial assistance of the present paper. The other authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2020/05/dic.2020-4-7-COI.pdf

Acknowledgements: Editorial assistance was provided by Aashni Shah, Barbara Bartolini, and Laura Brogelli, MD (Polistudium, Milan, Italy).

Funding declaration: Editorial assistance was supported by Welcare Industries.

Copyright: Copyright © 2020 Iacovelli NA, Torrente Y, Ciuffreda A, Guardamagna AV, Gentili M, Giacomelli L, Sacerdote P. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2020 Iacovelli NA, Torrente Y, Ciuffreda A, Guardamagna AV, Gentili M, Giacomelli L, Sacerdote P. https://doi.org/10.7573/dic.2020-4-7. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/topical-treatment-of-radiation-induced-dermatitis:-current-issues-and-potential-solutions

Correspondence: Luca Giacomelli, Polistudium SRL, Milan, Italy. luca.giacomelli@polistudium.it

Provenance: submitted; externally peer reviewed.

Submitted: 14 April 2020; Peer review comments to author: 4 May 2020; Revised manuscript received: 15 May 2020; Accepted: 18 May 2020; Publication date: 12 June 2020.

Drugs in Context is published by BioExcel Publishing Ltd. Registered office: Plaza Building, Lee High Road, London, England, SE13 5PT.

BioExcel Publishing Limited is registered in England Number 10038393. VAT GB 252 7720 07.

For all manuscript and submissions enquiries, contact the Editor-in-Chief gordon.mallarkey@bioexcelpublishing.com

For all permissions, rights and reprints, contact David Hughes david.hughes@bioexcelpublishing.com

Download free full text PDF