The benefits of antimicrobial photodynamic therapy with RLP068 in the management of diabetic foot ulcers

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Abstract

This article is the first part of a literature review concerning diabetic foot ulcers and the use of antimicrobial photodynamic therapy (PDT). Diabetic foot ulcers are associated with high morbidity, mortality, and healthcare costs. Natural healing is often delayed by microbial infection or colonisation, which might lead to serious complications, such as amputation. Furthermore, antibiotic treatment could have limited success because of the development of bacterial resistance and severely limited drug delivery to the ulcer due to vascular damage. PDT has antimicrobial effects and has been used to reduce the total and pathogenic microbial load in diabetic ulcers without inducing bacterial resistance. It is safe and can be used to improve outcomes. A clinical trial demonstrated that PDT with RLP068 reduced the microbial load of diabetic ulcers in 62 patients. This article reports previously published evidence and presents four, unpublished, clinical cases treated in the real-life setting.

Keywords: diabetic foot ulcer, ulcer therapy, photodynamic therapy, PDT.

Citation: Martinelli N, Curci V, Quarantiello A, Saldalamacchia G. The benefits of antimicrobial photodynamic therapy with RLP068 in the management of diabetic foot ulcers. Drugs in Context 2019; 8: 212610. DOI: 10.7573/dic.212610

Contributions: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2019/08/dic.212610-COI.pdf

Acknowledgments: Content Ed Net provided editorial assistance, with the helpful support of Laura Brogelli, PhD, in the drafting of the manuscript and of Mr Bilal Bham and Hussein Hijazi in the final reading of the manuscript for English language improvement. The authors thank Molteni Farmaceutici for unrestricted support.

Funding declaration: Editorial assistance was funded by Molteni Farmaceutici, Scandicci FI, Italy.

Copyright: Copyright © 2019 Martinelli N, Curci V, Quarantiello A, Saldalamacchia G. https://doi.org/10.7573/dic.212610. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2019 Martinelli N, Curci V, Quarantiello A, Saldalamacchia G. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/the-benefits-of-antimicrobial-photodynamic-therapy-with-rlp068-in-the-management-of-diabetic-foot-ulcers/

Correspondence: Nicolò Martinelli, IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi, 4, 20161 Milan, Italy. N.Martinelli@unicampus.it

Provenance: submitted; externally peer reviewed.

Submitted: 15 July 2019; Peer review comments to author: 25 July 2019; Revised manuscript received: 30 July 2019; Accepted: 31 July 2019; Publication date: 20 August 2019.

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