Satisfaction and quality of life of allergic patients following sublingual five-grass pollen tablet immunotherapy in Spain

Darío Antolín-Amerigo, Isabel A Tabar, Maria del Mar Fernández-Nieto, Anna M Callejo-Melgosa, Francisco J Muñoz-Bellido, José C Martínez-Alonso, Jorge D Méndez-Alcalde, Marta Reche, Ana Rodríguez-Trabado, Ana Rosado-Ingelmo, Alicia Alonso-Gómez, Rosa Blanco-González, José A Alvarez-Fernandez, Isabel Botella, Ana Valls, Mercedes Cimarra, Carlos Blanco


Background: Five-grass pollen tablet is an effective and well-tolerated therapy for patients with allergic rhinoconjunctivitis (ARC). This trial sought to determine the satisfaction and health-related quality of life (HRQoL) of patients undergoing this treatment.

Methods: This was a cross-sectional, multicentre, observational, naturalistic study, following a discontinuous pre- and coseasonal five-grass pollen regimen over two seasons in Spain (2012, 2013). The HRQoL of the patients was measured with the specific Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) for adults, adolescent (AdolRQLQ), or paediatric (PRQLQ) patients. Treatment satisfaction was assessed by the Satisfaction Scale for Patients Receiving Allergen Immunotherapy (ESPIA) questionnaire. Patients/investigators were surveyed on beliefs and attitudes towards the five-grass pollen tablet. ARC evolution according to allergic rhinitis and its impact on asthma (ARIA) criteria and treatment adherence were evaluated.

Results: Among the 591 ARC patients included, the mean (SD) HRQoL scores were 1.40 (1.1) in adults, 1.33 (1.1) in adolescents, and 1.15 (1.1) in children, indicating low levels of impairment (scale 0–6). ESPIA answers showed high levels of satisfaction, with an average score of 69.2 (scale 0–100). According to ARIA criteria, 88.2% of patients reported improvement of ARC. Moreover, this was accompanied by a reduced use of symptomatic medication. Adherence to treatment was estimated at 96.8%. In general, both patients and specialists exhibited a positive attitude towards five-grass pollen tablet treatment.

Conclusion: ARC patients treated with five-grass pollen tablet showed favourable levels of HRQoL and treatment satisfaction, with concomitant improvements in ARC and symptomatic medication use, which translated into high levels of treatment adherence and a positive attitude towards five-grass pollen tablet.

Article Details

Article Type

Original Research



Publication Dates

Accepted: ; Published: .


Antolín-Amerigo D, Tabar IA, Fernández-Nieto M, Callejo-Melgosa AM, Muñoz-Bellido FJ, Martínez-Alonso JC, Méndez-Alcalde JD, Reche M, Rodríguez-Trabado A, Rosado-Ingelmo A, Alonso-Gómez A, Blanco-González R, Alvarez-Fernandez JA, Botella I, Valls A, Cimarra M, Blanco C. Satisfaction and quality of life of allergic patients following sublingual fivegrass pollen tablet immunotherapy in Spain. Drugs in Context 2017; 6: 212309. DOI: 10.7573/dic.212309

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