Pharmacological treatment for attention deficit hyperactivity disorder: functional outcomes in children and adolescents from non-Western countries

Murat Altin, Ahmed A El-Shafei, Maria Yu, Durisala Desaiah, Tamas Treuer, Nikolay Zavadenko, Hong Yun Gao

Abstract

Objective: Functional outcomes were measured over a 12-month period in children and adolescents with attention deficit hyperactivity disorder (ADHD) after they received monotherapy. Design: Prospective, observational, noninterventional study.

Setting: Conducted in six non-Western countries.

Participants: Outpatients 6 to 17 years of age with a verified diagnosis of ADHD in accordance with the Diagnostic and Statistical Manual, Fourth Edition, Text Revision (DSM-IV-TR), together with their physicians, decided to initiate or switch treatment for ADHD. Patients were prescribed pharmacological monotherapy: methylphenidate (n=221), nootropic agents (n=91), or atomoxetine (n=234).

Measurements: Patients were followed for changes in their functional status and quality of life, which were assessed with the Child Health and Illness Profile–Child Edition (CHIPCE) Achievement domain.

Results: At the end of the study, a mean improvement on the CHIP-CE Achievement domain score was observed for all countries and therapies except in Taiwan, where patients received atomoxetine, and in Lebanon, where patients received methylphenidate. No patient experienced a serious adverse event during the study. Four patients discontinued due to a treatment-emergent adverse event.

Conclusion: After 12 months of treatment, clinical and functional outcomes were improved in children and adolescents from non-Western countries who initiated and remained on their prescribed pharmacological monotherapy.

Article Details

Article Type

Original Research

DOI

doi: 10.7573/dic.212260

Publication Dates

Published: .

Citation

Altin M, El-Shafei AA, Yu M, Desaiah D, Treuer T, Zavadenko NN, Gao HY. Pharmacological treatment for attention deficit hyperactivity disorder: functional outcomes in children and adolescents. Drugs in Context 2013;212260. doi: 10.7573/dic.212260

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