Neonatal pharmacology and clinical implications

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Abstract

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the main pharmacokinetic aspects (absorption, distribution, metabolism and excretion) that exist during the neonatal period, to offer a description of the physiological background for variability in pharmacological dosing.

Keywords: infant, newborn, pharmacology.

Citation: Ruggiero A, Ariano A, Triarico S, Capozza MA, Ferrara P, Attinà G. Neonatal pharmacology and clinical implications. Drugs in Context 2019; 8: 212608. DOI: 10.7573/dic.212608

Contributions: All authors contributed equally to the preparation of this review. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2019/09/dic.212608-COI.pdf

Acknowledgements: This work was technically supported by “Sara un angelo con la bandana Onlus”. We thank them for their dedicated patient care.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2019 Ruggiero A, Ariano A, Triarico S, Capozza MA, Ferrara P, Attinà G https://doi.org/10.7573/dic.212608. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2019 Ruggiero A, Ariano A, Triarico S, Capozza MA, Ferrara P, Attinà G. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/neonatal-pharmacology-and-clinical-implications/

Correspondence: Antonio Ruggiero, MD (ORCID 0000-0002-6052-3511), Paediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy. antonio.ruggiero@unicatt.it

Provenance: invited; externally peer reviewed.

Submitted: 5 July 2019; Peer review comments to author: 24 July 2019; Revised manuscript received: 10 September 2019; Accepted: 17 September 2019; Publication date: 14 October 2019.

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