Management of psoriasis in pregnancy – a review of the evidence to date

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Abstract

The onset of psoriasis collides with women’s reproductive timeframe, and pregnancy brings challenges to its treatment. Indeed, the health of both mother and foetus must be considered. When choosing to treat pregnant women affected by psoriasis with pharmacological therapy, it is important to be aware of all possible options and their repercussions. Although there are several pharmacological therapies available, pregnancy brings ethical concerns and any pharmacological approach must be well thought out. The data available in humans are limited, and further investigation on this matter is needed. Within biological therapies, certolizumab pegol has recently been identified as a promising approach during pregnancy because it has been shown to have no late active placental transfer and no clear signs of foetal harm. This article aims to review the impact of psoriasis during pregnancy, how the disease can be managed pharmacologically during this period according to the available armamentarium, and the possible effects of the therapeutic options for the mother and the foetus.

Keywords: pregnancy, pregnancy complications, psoriasis, therapy.

Citation: Ferreira C, Azevedo A, Nogueira M, Torres T. Management of psoriasis in pregnancy – a review of the evidence to date. Drugs in Context 2020; 9: 2019-11-6. DOI: 10.7573/dic.2019-11-6

Contributions: All authors contributed equally to the preparation of this review. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: Tiago Torres is a scientific consultant/speaker/clinical study investigator for AbbVie, Amgen, Arena Pharmaceuticals, Biocad, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Janssen, LEO-Pharma, Eli-Lilly, MSD, Novartis, Pfizer, Samsung-Bioepis, Sanofi-Genzyme and Sandoz. The other authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2020/01/dic.2019-11-6-COI.pdf

Acknowledgments: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2020 Ferreira C, Azevedo A, Nogueira M, Torres T. https://doi.org/10.7573/dic.2019-11-6. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2020 Ferreira C, Azevedo A, Nogueira M, Torres T. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/management-of-psoriasis-in-pregnancy-a-review-of-the-evidence-to-date/

Correspondence: Tiago Torres MD, PhD, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, and Department of Dermatology, Centro Hospitalar do Porto, Porto, Portugal. torres.tiago@outlook.com

Provenance: invited; externally peer reviewed.

Submitted: 25 November 2019; Peer review comments to author: 18 December 2019; Revised manuscript received: 8 January 2020; Accepted: 9 January 2020; Publication date: 9 March 2020.

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