Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus

Alexander KC Leung MBBS, FRCP (UK & Irel), FRCPCH, FAAP, Tara McMillan MD, FRCPC, Andrea Human MD, FRCPC, Joseph M Lam MD, FRCPC


Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. Physicians who treat children with HCQ for reasons such as rheumatologic disorders, dermatologic disorders and, more recently, coronavirus disease-19 should be aware of this less-known side effect of HCQ.

Article Details

Article Type

Case Report



Publication Dates

Accepted: ; Published: .


Leung AKC, McMillan T, Human A, Lam JM. Hydroxychloroquineinduced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus. Drugs in Context 2020; 9: 2020-5-8. DOI: 10.7573/dic.2020-5-8

Register for alerts

I would like to be contacted by Drugs in Context when new articles are posted.