Emollient treatment of atopic dermatitis: latest evidence and clinical considerations

Article Details

Authors
Kam Lun Hon MBBS, MD, FAAP, FCCM, Jeng Sum Charmaine Kung BSc, Wing Gi Gigi Ng BSc, Ting Fan Leung MBChB, MD, MRCP, FRCPCH

Article Type
Review

DOI
10.7573/dic.212530

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Abstract

Aim: To review current classes of emollients in the market, their clinical efficacy in atopic dermatitis (AD) and considerations for choice of an emollient.

Methods: PubMed Clinical Queries under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews were used as the search engine. Keywords of ‘emollient or moisturizer’ and ‘atopic dermatitis’ were used.

Overview of findings: Using the keywords of ‘emollient’ and ‘atopic dermatitis’, there were 105 and 36 hits under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews, respectively. Plant-derived products, animal products and special ingredients were discussed. Selected proprietary products were tabulated.

Conclusions: A number of proprietary emollients have undergone trials with clinical data available on PubMed-indexed journals. Most moisturizers showed some beneficial effects, but there was generally no evidence that one moisturizer is superior to another. Choosing an appropriate emollient for AD patients would improve acceptability and adherence for emollient treatment. Physician’s recommendation is the primary consideration for patients when selecting a moisturizer/ emollient; therefore, doctors should provide evidence-based information about these emollients.

Keywords: atopic dermatitis, emollient.

Citation: Hon KL, Kung JSC, Ng WGG, Leung TF. Emollient treatment of atopic dermatitis: latest evidence and clinical considerations. Drugs in Context 2018; 7: 212530. DOI: 10.7573/dic.212530

Disclosure and potential conflicts of interest: The authors declare no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at: https://www.drugsincontext.com/wp-content/uploads/2018/03/dic.212530-COI.pdf

Copyright: Copyright © 2018 Hon KL, Kung JSC, Ng WGG, Leung TF. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2018 Hon KL, Kung JSC, Ng WGG, Leung TF. https://doi.org/10.7573/dic.212530. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/emollient-treatment-of-atopic-dermatitis-latest-evidence-and-clinical-considerations

Correspondence: Kam Lun Hon, Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong. ehon@cuhk.edu.hk

Provenance: invited; externally peer reviewed.

Submitted: 26 January 2018; Peer review comments to author: 16 February 2018; Revised manuscript received: 11 March 2018; Accepted: 14 March 2018; Publication date: 17 April 2018.

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