Volume matters and intensification is needed: emerging trends in the management of advanced prostate cancer

Iris Y Sheng, Pedro Barata, Raafat Alameddine, Jorge A Garcia

Abstract

Significant changes in the management of patients with de novo metastatic prostate cancer have led to the use of novel oral agents and docetaxel-based chemotherapy earlier in the natural history of their disease. Our main challenge is the lack of prospective randomized data comparing these regimens. It is clear that treatment intensification is needed. Yet, the heterogeneity of this patient population coupled with the lack of understanding of the specific biology for a given individual makes treatment selection challenging. The aim of this narrative review is to discuss the importance of defining advanced disease by volume, the necessity for treatment intensification, and the current and future landscape of metastatic hormone-sensitive prostate cancer management.

Article Details

Article Type

Review

DOI

10.7573/dic.2020-10-2

Publication Dates

Accepted: ; Published: .

Citation

Sheng IY, Barata P, Alameddine R, Garcia JA. Volume matters and intensification is needed: emerging trends in the management of advanced prostate cancer. Drugs in Context 2021; 10: 2020-10-2. DOI: 10.7573/dic.2020-10-2

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