Volume matters and intensification is needed: emerging trends in the management of advanced prostate cancer

Article Page

Abstract

Significant changes in the management of patients with de novo metastatic prostate cancer have led to the use of novel oral agents and docetaxel-based chemotherapy earlier in the natural history of their disease. Our main challenge is the lack of prospective randomized data comparing these regimens. It is clear that treatment intensification is needed. Yet, the heterogeneity of this patient population coupled with the lack of understanding of the specific biology for a given individual makes treatment selection challenging. The aim of this narrative review is to discuss the importance of defining advanced disease by volume, the necessity for treatment intensification, and the current and future landscape of metastatic hormone-sensitive prostate cancer management.

Keywords: de novo, metastatic prostate cancer, treatment intensification, trends, volume status.

Citation: Sheng IY, Barata P, Alameddine R, Garcia JA. Volume matters and intensification is needed: emerging trends in the management of advanced prostate cancer. Drugs in Context 2021; 10: 2020-10-2. DOI: 10.7573/dic.2020-10-2

Contributions: All authors contributed equally in the conception, planning and drafting of the manuscript and have approved the final submitted version. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2021/02/dic.2020-10-2-COI.pdf

Acknowledgements: None.

Funding declaration: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector.

Copyright: Copyright © 2021 Sheng IY, Barata P, Alameddine R, Garcia JA. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2021 Sheng IY, Barata P, Alameddine R, Garcia JA. https://doi.org/10.7573/dic.2020-10-2. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/volume-matters-and-intensification-is-needed:-emerging-trends-in-the-management-of-advanced-prostate-cancer

Correspondence: Jorge A Garcia, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Lakeside Suite 1200, Cleveland, OH 44106, USA. Email: jorge.garcia@uhhospitals.org

Provenance: Invited; externally peer reviewed.

Submitted: 12 October 2020; Accepted: 7 February 2020; Publication date: 15 March 2021.

Drugs in Context is published by BioExcel Publishing Ltd. Registered office: Plaza Building, Lee High Road, London, England, SE13 5PT.

BioExcel Publishing Limited is registered in England Number 10038393. VAT GB 252 7720 07.

For all manuscript and submissions enquiries, contact the Editorial office editorial@drugsincontext.com

For all permissions, rights and reprints, contact David Hughes david.hughes@bioexcelpublishing.com

Download free full text PDF