The therapeutic role of minocycline in Parkinson’s disease

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Abstract

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline may have some neuroprotective activity in various experimental models such as cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, Parkinson’s disease (PD), Huntington’s disease, and multiple sclerosis. In this perspective review, we summarize the preclinical and clinical findings suggesting the neuroprotective role of minocycline in PD.

Keywords: minocycline, neurodegeneration, neuroprotection, Parkinson’s disease.

Citation: Cankaya S, Cankaya B, Kilic U, Kilic E, Yulug B. The therapeutic role of minocycline in Parkinson’s disease. Drugs in Context 2019; 8: 212553. DOI: 10.7573/dic.212553

Contributions: S Cankaya, B Cankaya and B Yulug were responsible for writing the article; E Kilica and U Kilic were responsible for revising the article; E Kilic and U Kilic carried out a language check of the article; S Cankaya and B Cankaya prepared the data for the article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at https://www.drugsincontext.com/wp-content/uploads/2019/02/dic.212553-COI.pdf

Acknowledgments: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2019 Cankaya S, Cankaya B, Kilic U, Kilic E, Yulug B. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2019 Cankaya S, Cankaya B, Kilic U, Kilic E, Yulug B. https://doi.org/10.7573/dic.212553. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/the-therapeutic-role-of-minocycline-in-parkinsons-disease

Correspondence: Seyda Cankaya, Department of Neurology, Faculty of Medicine, Alaaddin Keykubat University, Alanya, Turkey. seyda.cankaya@alanya.edu.tr

Provenance: invited; externally peer reviewed.

Submitted: 9 August 2018; Peer review comments to author: 26 November 2018; Revised manuscript received: 20 January 2019; Accepted: 22 January 2019; Publication date: 6 March 2019.

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