Role of betamethasone valerate 2.250 mg medicated plaster in the treatment of psoriasis and other dermatological pathologies: a review

Article Page

Abstract

Treating dermatological pathologies with topical corticosteroids under occlusion is often more effective than nonocclusive therapy, especially in the treatment of psoriasis. Betamethasone valerate medicated plaster provides a controlled and localized method of dosing betamethasone valerate, a well-established corticosteroid with vasoconstrictive, anti-inflammatory, immunosuppressive, and antiproliferative properties. This self-adhesive plaster is approved for the treatment of inflammatory skin disorders that do not respond to treatment with less potent corticosteroids. As a patch, it offers all the clinical benefits of occlusive therapy such as increased penetration of topical agent into the area requiring treatment, enhanced skin hydration, and protection from local trauma or scratching. This translates into improved patient compliance, which is notoriously low in patients with dermatological conditions. This review presents the available clinical data from studies with betamethasone valerate medicated plaster in the treatment of psoriasis and other dermatoses and discusses its place in therapy for dermatological conditions.

Keywords: betamethasone valerate, corticosteroids, dermatoses, medicated plaster, pharmacokinetics, psoriasis, skin disorders, treatment.

Citation: Amici JM, Ly S. Role of betamethasone valerate 2.250 mg medicated plaster in the treatment of psoriasis and other dermatological pathologies: a review. Drugs in Context 2018; 7: 212539. DOI: 10.7573/dic.212539

Contributions: Drs Amici and Ly contributed in searching literature, drafting, and conceptually revising the manuscript.

Disclosure and potential conflicts of interest: Dr Amici reports personal fees from Roche, Leo Pharma, Zambon outside the submitted work. Dr Ly reports personal fees from GENEVRIER during the conduct of the study as well as personal fees from Lilly, Leo, Novartis, MEDA outside the submitted work. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at https://www.drugsincontext.com/wp-content/uploads/2018/07/dic.212539-COI.pdf

Funding declaration: Article processing charges were funded by IBSA Institut Biochimique SA.

Copyright: Copyright © 2018 Amici JM, Ly S. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2018 Amici JM, Ly S. https://doi.org/10.7573/dic.212539. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/role-of-betamethasone-valerate-2250-mg-medicated-plaster-in-the-treatment-of-psoriasis-and-other-dermatological-pathologies-a-review

Correspondence: Jean Michel Amici, Department of Dermatology, Saint André Hospital, 1 Rue Jean Burguet, 33000, Bordeaux, France. jmamici@gmail.com

Provenance: submitted; externally peer reviewed.

Submitted: 28 May 2018; Peer review comments to author: 5 July 2018; Revised manuscript received: 10 July 2018; Accepted: 11 July 2018; Publication date: 20 August 2018.

Drugs in Context is published by BioExcel Publishing Ltd. Registered office: Plaza Building, Lee High Road, London, England, SE13 5PT.

BioExcel Publishing Limited is registered in England Number 10038393. VAT GB 252772009.

For all manuscript and submissions enquiries, contact the Editorial office dic.editorial@bioexcelpublishing.com

For all permissions, rights, and reprints, contact David Hughes david.hughes@bioexcelpublishing.com

Download free full text PDF