Nail enthesis ultrasound and automated software-guided assessment of bilateral common carotid intima–media thickness in psoriasis and psoriatic arthritis: is there a correlation with clinical and laboratory findings?

Article Details

Authors
José Alexandre Mendonça PhD, Lucas Nogueira Pansani MD, Mateus Basso Mimoto MD, Igor Tadeu Garcia Ferreira MD, Fernanda Bertucci Sanches MD, Thais de Campos Ferreira Pinto MD, Vania Aparecida Leandro-Merhi PhD, José Luis Braga de Aquino PhD

Article Type
Original Research

DOI
10.7573/dic.2020-1-2

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Abstract

Background: Ultrasound (US) in psoriasis (PsO) and psoriatic arthritis (PsA) is an important tool in several situations to detect joint ecostructural damage as well as other tissue alterations, such as those that occur in the larger vessels. The objective of this study was to detect and correlate the changes that indicate the inflammatory and atherosclerotic process in two groups of patients, using nail US and carotid artery intima–media thickness radiofrequency (RF) software.

Methods: A total of 30 patients diagnosed with (PsO) and (PsA) were selected. About 15 patients were present in each group, assigned by the Dermatology and Rheumatology Service of the Universidade Pontifícia Católica de Campinas, São Paulo, Brazil, and were assessed using carotid artery US (radiofrequency quality intima–media thickness [RF-QIMT]), joint US, clinical evaluation, and laboratory tests.

Results: Spearman and Pearson correlations between US variables per group were Psoriasis Area and Severity Index (PASI) and loss of the nail pattern trilaminar: r=0.658, p=0.015; Framingham Score (FS) and Internal Resistance Index (IR): 0.351 to 0.526, p=0.034 to 0.002; the significant correlations by the Bayesian factor (BF) were those with a BF greater than 2.5, between QIMT expected with FS: r=0.677, BF=10.06, with total cholesterol: r=0.5232, BF=2.60, and QIMT-RF with low density lipoproteins: r=0.633, BF=3.70.

Conclusion: The use of US in the evaluation of these patients showed significant correlations between clinical and laboratory measures, characterized by QIMT and FS as well as changes in nail insertion. Future studies may demonstrate an even better interaction.

Keywords: atherosclerosis, carotid artery, psoriasis, psoriatic arthritis, spectral Doppler, ungueal disease.

Citation: Mendonça JA, Pansani LN, Mimoto MB, Ferreira ITG, Sanches FB, Pinto TFC, Leandro-Merhi VA, Aquino JLB. Nail enthesis ultrasound and automated software-guided assessment of bilateral common carotid intima–media thickness in psoriasis and psoriatic arthritis: is there a correlation with clinical and laboratory findings? Drugs in Context 2020; 9: 2020-1-2. DOI: 10.7573/dic.2020-1-2

Contributions: All authors are part of the medical team of the Pontifical Catholic University of Campinas and contributed to the methodological and clinical aspects of the article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2020/05/dic.2020-1-2-COI.pdf

Acknowledgements: The authors thank the patients of the Dermatology and Rheumatology Service of the Pontifical Catholic University of Campinas, Brazil.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2020 Mendonça JA, Pansani LN, Mimoto MB, Ferreira ITG, Sanches FB, Pinto TFC, Leandro-Merhi VA, Aquino JLB. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2020 Mendonça JA, Pansani LN, Mimoto MB, Ferreira ITG, Sanches FB, Pinto TFC, Leandro-Merhi VA, Aquino JLB. https://doi.org/10.7573/dic.2020-1-2. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/nail-enthesis-ultrasound-and-automated-software-guided-assessment-of-bilateral-common-carotid-intima-media-thickness-in-psoriasis-and-psoriatic-arthritis:-is-there-a-correlation-with-clinical-and-laboratory-findings?

Correspondence: José Alexandre Mendonça, Sumaré, São Paulo, CEP 13175-665, Brazil. mendoncaja.us@gmail.com

Provenance: submitted; externally peer reviewed.

Submitted: 23 January 2020; Peer review comments to author: 1 April 2020; Revised manuscript received: 1 May 2020; Accepted: 4 May 2020; Publication date: 3 June 2020.

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