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Menopause hormone therapy (MHT) is the most efficient treatment for symptoms of acute climacteric syndrome and for efficient prevention of long-term estrogen deficiency. Vaginal administration of low doses of estrogen is a therapy of choice for treatment and prevention of urogenital atrophy and its consequences. Systemic treatment may include estrogen, but an equally efficient alternative is tibolone. Nonhormonal therapy relies on phytoestrogens, black cohosh extract, and serotonin reuptake inhibitors.

Keywords: atrophic vaginitis, bazedoxifene, climacteric syndrome, menopause hormone therapy, phytoestrogens, tibolone.

Citation: Fait T. Menopause hormone therapy: latest developments and clinical practice. Drugs in Context 2019; 8: 212551. DOI: 10.7573/dic.212551

Contributions: The author meets the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The author declares that there is no conflict of interest in preparing this article. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at https://www.drugsincontext.com/wp-content/uploads/2018/12/dic.212551-COI.pdf

Acknowledgments: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2019 Fait T. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2019 Fait T. https://doi.org/10.7573/dic.212551. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/menopause-hormone-therapy:-latest-developments-and-clinical-practice

Correspondence: Tomas Fait, Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. tfait@seznam.cz

Provenance: invited; externally peer reviewed.

Submitted: 12 July 2018; Peer review comments to author: 21 August 2018; Revised manuscript received: 10 December 2018; Accepted: 10 December 2018; Publication date: 2 January 2019.

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