From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease

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Abstract

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia.

Keywords: Parkinson’s disease, levodopa, therapy, deep brain stimulation.

Citation: Nagao KJ, Patel NJ. From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease. Drugs in Context 2019; 8: 212592. DOI: 10.7573/dic.212592

Contributions: Dr Kanae J Nagao wrote the first draft and was involved in editing of the manuscript. Dr Neepa J Patel was involved with concept and editing of the manuscript. Both authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: Dr Kanae J Nagao reports no conflicts of interest. A/Professor Neepa J Patel has received honoraria as a consultant for Acadia Pharmaceuticals and Medtronic and as a speaker for Teva Pharmaceuticals and US World Meds. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2019/08/dic.212592-COI.pdf

Acknowledgments: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2019 Nagao KJ, Patel NJ. https://doi.org/10.7573/dic.212592. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2019 Nagao KJ, Patel NJ. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/from-medications-to-surgery:-advances-in-the-treatment-of-motor-complications-in-parkinson’s-disease/

Correspondence: A/Professor Neepa J Patel, Department of Neurology, Henry Ford Health System, West Bloomfield, Michigan, USA. npatel20@hfhs.org

Provenance: invited; externally peer reviewed.

Submitted: April 1, 2019; Peer review comments to author: May 13, 2019; Revised manuscript received: June 19, 2019; Accepted: June 25, 2019; Publication date: August 13, 2019.

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