Efficacy of cyclophosphamide in treating connective tissue disease-related interstitial lung diseases

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Authors
Valeria Nucera MD, Elisabetta Gerratana MD, Manuela Giallanza MD, Laura La Corte MD, Donatella Sangari MD, Fabiola Atzeni MD, PhD

Article Type
Review

DOI
10.7573/dic.2020-9-1

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Abstract

Interstitial lung diseases (ILDs) are some of the first and most serious complications of connective tissue diseases (CTDs). However, the pathogenesis of CTD-related ILDs (CTD-ILDs) is still unclear and their treatment often depends on functional and radiographic disease progression as well as on patient age and comorbidities. It can be difficult to manage CTD-ILDs due to their heterogeneous nature, the lack of robust therapeutic data, and the few well-defined outcome measures. This review focuses on cyclophosphamide due to its crucial role in the treatment of systemic sclerosis-related ILD, particularly in the case of patients with progressive ILD. This narrative review was performed using PubMed, Medline, and Cochrane Library databases to retrieve English language papers published between 2000 and April 2020 concerning the treatment of CTD-ILDs with cyclophosphamide.

Keywords: comorbidities, connective tissue diseases, cyclophosphamide, disease-modifying antirheumatic drugs, interstitial lung diseases.

Citation: Nucera V, Gerratana E, Giallanza M, La Corte L, Sangari D, Atzeni F. Efficacy of cyclophosphamide in treating connective tissue disease-related interstitial lung diseases. Drugs in Context 2021; 10: 2020-9-1. DOI: 10.7573/dic.2020-9-1

Contributions: VN and FA contributed equally to this paper. VN, MG, LLC, and EG participated in the literature search; FA and VN drafted the manuscript, which was critically reviewed by FA and DS. All of the authors read and approved the final manuscript. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no potential conflicts of interest with respect to the research, authorship, or publication of this article. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2020/11/dic.2020-9-1-COI.pdf

Acknowledgements: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2021 Nucera V, Gerratana E, Giallanza M, La Corte L, Sangari D, Atzeni F. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2021 Nucera V, Gerratana E, Giallanza M, La Corte L, Sangari D, Atzeni F. https://doi.org/10.7573/dic.2020-9-1. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/efficacy-of-cyclophosphamide-in-treating-connective-tissue-disease-related-interstitial-lung-diseases

Correspondence: Fabiola Atzeni, Rheumatology Unit, University of Messina, Via C. Valeria 1, 98100 Messina, Italy. atzenifabiola@hotmail.com

Provenance: Invited; externally peer reviewed.

Submitted: 2 September 2020; Accepted: 14 November 2020; Publication date: 15 January 2021.

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